Splenomegaly in sarcoidosis: Frequency, treatment, prognosis and long-term follow-up

Abstract

Splenomegaly was more frequent in chronic cases or in the patients with established sarcoid lesions of other extrapulmonary organs.The primary treatment of uncomplicated symptomatic splenic sarcoidosis includes medicamentous therapy. Occasionally, splenectomy is required. Prognostically, splenomegaly indicates an unfavorable course of the disease.

The Diagnosis and Response to Treatment of an Extrapulmonary Sarcoidosis on F18-FDG PET/CT: A Case Report

“…Liver involvement is 5-15%. Spleen involvement ranges from 1% to 40% [5][6]. Spleen, liver and skin involvement, as found in this case, is an extremely rare combination in the literature.…”

“The Great Mimicker”: An Unusual Etiology of Cytopenia, Diffuse Lymphadenopathy, and Massive Splenomegaly

“…In this setting, bilateral hilar adenopathy, with or without interstitial lung disease, is a common finding. Extrathoracic sarcoidosis is also common, with liver and spleen involvement described in half of autopsy cases [ 2 , 3 ]. Other commonly involved organs are the skin, the joints, and the eyes.…”

“…Sarcoidosis is a chronic inflammatory disorder of unknown origin which occurs mainly in young people [ 1 , 2 ]. It is characterized by the presence of noncaseating granulomas.…”

“…Although the lung is the most common organ involved, the disease can affect any organ, including the spleen [ 1 ]. Granulomatous infiltration of the spleen is common in sarcoidosis and is often asymptomatic [ 2 ]. Splenomegaly is unusual, and massive splenomegaly is very rare [ 3 ].…”

Bone marrow involvement in sarcoidosis: an elusive extrapulmonary manifestation

“…Several organ systems can be affected in sarcoidosis. Prevalence of splenomegaly is 26% and increases when other concomitant extrapulmonary lesions are present [48]. Neurologic complications in sarcoidosis can occur in 3-10% of cases, with cranial neuropathy and meningeal disease being the most commonly reported [49].…”