Splenic size determination in sickle cell anaemia: an ultrasonographic study

Olatunji, Abolarin; Olatunji, PO

doi:10.4314/eamj.v78i7.9010

Cited by 8 publications

(13 citation statements)

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“…This implies that, in our locality, the spleen of patients with SCD increases rapidly in size from early age and peaks at 18 years, and generally declines sharply to either a shrunken state or auto-splenectomy. This trend contradicts the findings of previous authors 12,13,[15][16][17] probably because of differences in study protocol, clime and haplotype. It can also be related to high malaria endemicity and frequent bacterial infections that may cause hypertrophy and hyperplasia of the spleen in our environment.…”

Section: Discussioncontrasting

confidence: 57%

“…This is consistent with the findings of other previous authors. 18,20 However, this contradicts the findings of significant correlation between age and spleen sizes by other researchers 16,17,21 which could be as a result of differences in ethnicity, clime and haplotype. There is positive correlation between mean spleen sizes and age (P = 0.00, r = 0.67), height (P = 0.00, r = 0.90), and weight (P = 0.00, r = 0.87) in the control subjects.…”

Section: Discussioncontrasting

confidence: 56%

“…This could be due to low body immunity in this age range with resultant high susceptibility of SCD subjects to the acute complications of sickle cell condition. This result agrees with the findings of previous works 12,16,21 possibly because of similarity in study protocol, but disagrees with the work of Babadoko et al 13 in Zaria, Nigeria.…”

Section: Discussioncontrasting

confidence: 43%

“…10,11 Regional variations in splenic size and spleen parenchyma echo-texture among sickle cell disease (SCD) patients exist in different publications. [12][13][14][15][16] No such study has been documented in our locality.…”

Section: Introductionmentioning

confidence: 99%

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Sonographic evaluation of the spleen among sickle cell disease patients in a teaching hospital in Nigeria

et al. 2015

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Background: Regional variations in size and parenchyma echo-texture of the spleen among sickle cell disease (SCD) patients have been documented in various publications. The objectives of this study were to assess the size and parenchyma echo-texture of the spleen of SCD patients and ascertain the relationship of age, height and weight with the spleen sizes. Methods: This was a cross sectional study involving 103 each of SCD and age matched control subjects. Aloka ST-550 -3500 ultrasound machine with 3.5 and 5 MHz convex transducers was used to scan the subjects over a 15 months period (September, 2012 to November, 2013. The age, height and weight of each subject were recorded. Results: The spleen sizes of SCD patients were generally larger than those of the controls (p < 0.05). Abnormal spleen parenchyma of varied appearances was found among the SCD subjects. There were negative correlations between mean spleen sizes and height, weight and age in SCD patients but positive correlations were found between them in the controls. Conclusion: Routine sonographic assessment of spleen size and echo-texture is useful in the management of SCD patients. Sci. 2015;15(3):949-58. doi: http://dx.doi.org/10.4314/ahs.v15i3.32

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Section: Discussioncontrasting

confidence: 57%

Section: Discussioncontrasting

confidence: 56%

Section: Discussioncontrasting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

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Sonographic evaluation of the spleen among sickle cell disease patients in a teaching hospital in Nigeria

et al. 2015

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“…(Eze et al, 2015) However, other researchers found significant correlation between age and spleen size. (Olatunji & Olatunji, 2001; Al-Salem et al, 1998) Acute splenic sequestration crisis is a potentially life-threatening complication and is known to one of the leading causes of death in children with sickle cell disease. Surprisingly in this study,the diagnosis of acute splenic sequestration in children group was not reported.…”

Section: Extra-splenic Findings:-mentioning

confidence: 99%

Computed Tomography Findings in the Spleen of Sickle Cell Patients in Saudi Arabia.

Alalwan¹

2018

IJAR

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Persistent splenomegaly in an adult female with homozygous sickle cell anemia

Singh

Gupta

et al. 2006

Hematology

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Sickle cell anemia (SCA) is associated with repeated episodes of erythrostasis in the spleen, which lead to thrombosis and infarction of the spleen resulting in "autosplenectomy" which is usually complete by 8 years of age. We present a case of a 22-year-old female who presented with complaints of fever, bone pain and joint swelling. On examination she had pallor, icterus and moderate splenomegaly. Her hemoglobin was 7.5 g/dl. Peripheral smear showed many sickled red cells. Slide test for sickling was positive with 2% sodium metabisulphite. Hemoglobin electrophoresis revealed a single band in the hemoglobin S, D, and G region. No band was seen in the HbA & HbA(2) region. HbF level was 0%. USG showed an enlarged spleen with few defined hypoechoeic lesion. We present this case because of rarity of association of homozygous SCA with splenomegaly in this age group, the confusion that echogenic lesions in spleen can create and to emphasize the risk of sequestration crises, which remains in such cases.

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Splenic size determination in sickle cell anaemia: an ultrasonographic study

Cited by 8 publications

References 0 publications

Sonographic evaluation of the spleen among sickle cell disease patients in a teaching hospital in Nigeria

Sonographic evaluation of the spleen among sickle cell disease patients in a teaching hospital in Nigeria

Computed Tomography Findings in the Spleen of Sickle Cell Patients in Saudi Arabia.

Persistent splenomegaly in an adult female with homozygous sickle cell anemia

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