Splenic sea-blue (ceroid) histiocytosis due to hypertriglyceridemia: Report of a case and review of literature

Krehbiel, Kacy; Glew, Robert H.; Modi, Sheila; Vasef, Mohammad A.

doi:10.1016/j.ehpc.2016.03.007

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Besides ITP as in our patient, they could be a secondary finding associated with a wide range of non-malignant disorders where bone marrow has rapid cell turnover and infiltration as seen in thalassemia, severe autoimmune neutropenia, lipid storage diseases such as Gaucher disease and Niemann-Pick disease, and in patients receiving prolonged total parenteral nutrition and isolated hypertriglyceridemia [ 2 - 5 ]. Even rarely, SBH can be seen in a genetic syndrome variably called as primary or idiopathic sea‑blue histiocytosis or inherited lipemic splenomegaly, characterized by purpura, hypertriglyceridemia, thrombocytopenia, splenomegaly and progressive liver failure [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Sea Blue Histiocytosis Concordant With Immune Thrombocytopenic Purpura

Bhardwaj

Gupta

Tahlan

et al. 2020

Cureus

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Sea blue histiocytosis is an unusual bone marrow finding in many haematological conditions or lipid metabolic diseases that by itself may not carry any prognostic value. It may occur rarely as a primary genetic clinical syndrome characterized by splenomegaly, hypertriglyceridemia and thrombocytopenia. More commonly, the presence of these lipid-laden blue-stained macrophages indicates an underlying condition characterized by increased bone marrow precursor cell turnover due to myeloproliferative conditions or ineffective erythropoiesis. Rarely may they be observed in cases of immune thrombocytopenic purpura (ITP) incidentally due to rapid megakaryocytic turnover. Sea blue histiocytosis should prompt the clinician to evaluate the patient for more sinister conditions such as myelodysplastic syndrome or infiltrative disorders.

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Section: Discussionmentioning

confidence: 99%

Sea Blue Histiocytosis Concordant With Immune Thrombocytopenic Purpura

Bhardwaj

Gupta

Tahlan

et al. 2020

Cureus

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Sea Blue Histiocytosis with Thrombocytopenia – A Review

Jamal¹,

Raman²,

Choudhary³

2020

jebmh

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Sea blue histiocytosis is generally seen where the turnover of cells is high like in certain haematological malignancies like myelodysplastic syndromes, chronic myeloproliferative neoplasms, immune thrombocytopenias and lipid storage disorders etc. Most commonly involved organs are bone marrow, spleen and liver. We report a case of 32 year old male who was Hepatitis B positive and presented with thrombocytopenia. Bone marrow examination revealed presence of numerous sea blue histiocytes. Extensive haematological and biochemical investigations failed to find out the cause of thrombocytopenia with presence of sea blue histiocytes in bone marrow, that makes our case worth reporting. This present case highlights the necessity of good communication between clinicians and pathologists for the identification of this uncommon disorder. A PubMed search of literature review was done from 1972 to 2019 in order to find out the overall incidence of this rare entity and the various other differential diagnoses were discussed. KEYWORDS Sea Blue, Histiocytosis, Thrombocytopenia, Haematological, Malignancies, PubMed.

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Splenic sea-blue (ceroid) histiocytosis due to hypertriglyceridemia: Report of a case and review of literature

Cited by 2 publications

References 22 publications

Sea Blue Histiocytosis Concordant With Immune Thrombocytopenic Purpura

Sea Blue Histiocytosis Concordant With Immune Thrombocytopenic Purpura

Sea Blue Histiocytosis with Thrombocytopenia – A Review

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