Splenic rupture: a rare presentation of metastatic choriocarcinoma

Nethra, S.; Hawe, Jed; Elder, Jackie

doi:10.1007/s10397-010-0630-z

Cited by 6 publications

(6 citation statements)

References 2 publications

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“…Choriocarcinoma metastasis are most commonly in the lungs (80%) followed by vagina (30%), pelvis (20%), and brain (10%) [5]. Rarer presentation of metastasis include splenic rupture or hepatic metastasis, how unusual presentation of small bowel lesions along with intussusception is very rare [6][7][8][9][10]. Also, this patient was unfortunate to have metastasis in lungs, spleen, liver, brain.…”

Section: Discussionmentioning

confidence: 89%

Multi-organ Metastatic Choriocarcinoma with Rare Presentation of Small Bowel Intussusception

Sayani¹,

Qamari²,

Raza³

et al. 2017

J Perioper Med

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We report the case of a 30-years-old lady who presented with primary complains of GI bleed since 4 months. Her upper and lower GI endoscopies were inconclusive due to luminal blood. CT scan abdomen showed multi organ haemorrhagic lesions, including liver, lung, spleen, kidneys and bowel. The lesion in small bowel was leading to intussusception. No definite arterial extravasation was seen. Her RBC tag was also negative. Due to continuous bleeding and her clinical condition she was advised for angiography which demonstrated vascular lesions in the small bowel. These were embolized to reduce vascularity and bleeding. Post embolization, the patient had to be shifted for laparotomy due to abdominal pain. Resection and anastomosis with temporary ileostomy was performed due to multiple small bowel lesions and biopsy from liver was also performed. Histopathology report showed choriocarcinoma. Her consciousness level deteriorated and CT scan of brain was done which showed metastatic lesions in brain. Patient's condition continued to deteriorate and she died few days later.

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Section: Discussionmentioning

confidence: 89%

Multi-organ Metastatic Choriocarcinoma with Rare Presentation of Small Bowel Intussusception

Sayani¹,

Qamari²,

Raza³

et al. 2017

J Perioper Med

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“…All patients presented with abdominal pain, and only one patient had per vaginal bleeding. 5 Four patients achieved remission after chemotherapy. One patient died due to progression of the disease, 6 as he could not tolerate chemotherapy due to his poor physical condition.…”

Section: Discussionmentioning

confidence: 97%

“…Spontaneous rupture of splenic metastases with hemoperitoneum is rare and there are only five case reports. 1 2 4 5 6 Table 1 provides a summary of all five case reports. All patients presented with abdominal pain, and only one patient had per vaginal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic splenectomy for splenic rupture secondary to metastatic choriocarcinoma

Aloysius

Shelat

2018

Ann Hepatobiliary Pancreat Surg

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Gestational choriocarcinoma is a rare and aggressive type of gestational trophoblastic neoplasia, which is characterized by early vascular invasion and widespread metastases. Choriocarcinoma metastasizes hematogenously, and bleeding from metastases is common. Splenic rupture from a metastatic tumour is exceedingly rare, with only a few reports. We report a case of a 41-year-old female presenting with acute abdomen and haemorrhagic shock secondary to splenic rupture from metastatic choriocarcinoma, which was managed with emergency laparoscopic splenectomy.

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“…1 Atraumatic rupture caused by splenic metastasis of choriocarcinoma is rare, and only six cases have been reported. [7][8][9][10][11][12] Choriocarcinoma is characterized by secretion of high HCG levels. Blood b-HCG levels in our patient were >15,000 mIU/mL, and she had multiple liver and spleen lesions, a suspicious ruptured spleen, and massive hemoperitoneum.…”

Section: Discussionmentioning

confidence: 99%

Ultra-high-risk choriocarcinoma with atraumatic splenic rupture: a rare case report

Zhang

et al. 2021

J Int Med Res

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Choriocarcinoma is a malignant tumor associated with early vascular invasion and a high mortality. Ultra-high-risk choriocarcinoma, which was proposed in the International Federation of Gynecology and Obstetrics cancer report of 2018, has a higher risk of treatment failure and a worse prognosis than choriocarcinoma. We report a rare case of a 39-year-old female patient with ultra-high-risk choriocarcinoma (stage IV:20) with hemorrhage secondary to atraumatic splenic rupture as the initial sign. A satisfactory outcome was achieved through comprehensive treatment with surgery, chemotherapy, immunotherapy, and targeted therapy.

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Splenic rupture: a rare presentation of metastatic choriocarcinoma

Cited by 6 publications

References 2 publications

Multi-organ Metastatic Choriocarcinoma with Rare Presentation of Small Bowel Intussusception

Multi-organ Metastatic Choriocarcinoma with Rare Presentation of Small Bowel Intussusception

Laparoscopic splenectomy for splenic rupture secondary to metastatic choriocarcinoma

Ultra-high-risk choriocarcinoma with atraumatic splenic rupture: a rare case report

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