Splenic red pulp macrophages eliminate the liver-resistantStreptococcus pneumoniaeduring bloodstream infection
Yijia Huang,
Zhifeng Zhao,
Kunpeng Li
et al.
Abstract:The spleen is well-known for defense against invasive infections of encapsulated bacteria, particularly Streptococcus pneumoniae (pneumococcus). However, the precise mechanism of the splenic anti-bacterial immunity remains elusive. Here we report that red pulp (RP) macrophages execute the splenic defense against S. pneumoniae in mice, with the help of natural antibodies (nAbs) and complement system. The spleen slowly but substantially cleared encapsulated pneumococci from the bloodstream in the early phase of … Show more
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