Splenic reactions to colloidal thorium dioxide in the albino rat

Baillif, Ralph N.

doi:10.1002/aja.1000920103

Cited by 15 publications

(2 citation statements)

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“…It is known that arterial terminals of the white pulp (PALS and follicle) of some mammalian spleens dilate and envelop the white pulp (follicles) to form a peculiar structure known as the marginal sinus (Snook, 1964;Hayes, 1973). Synonyms of the marginal sinus include "intermediate sinus" (Andrew, 19461, "perifollicular space" (Altschul and Hummarson, 1947;Snook, 1950), and "marginal sinusoid" (Baillif, 1953). The marginal sinus is most apparent in the rodent spleen, particularly the mouse and rat, and may not be seen in spleens of many mammalian species (guinea pig, rabbit, dog, and man;Tischendorf, 1969).…”

Section: Structure Of the Insectivore Spleenmentioning

confidence: 99%

“…This zone appears to be interposed between the white and red pulp and is named the intermediate zone (IZ) (Tanaka, 1986a), distinguishing it from the marginal zone (MZ) (Altschul and Hummason, 1947;Snook, 1950), which is located a t the same topographical site in the spleen of common mammals (Snook, 1950). Synonyms for the MZ include "Knotchenrandzone" (Weidenreich, 1901), "border or outer zone of the follicle" (Andrew, 19461, "perifollicular envelope" (Krumbharr, 1948), and "white pulp halo" (Baillif, 1953). Histologically, plexiform vessels of the IZ are separated by a thin layer of connective tissue.…”

Section: Introductionmentioning

confidence: 99%

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“Intermediate zone” of mammalian spleens: Light and electron microscopic study of three primitive mammalian species (platypus, shrew, and mole) with special reference to intrasplenic arteriovenous communication

Tanaka

1990

Am. J. Anat.

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The intermediate zone (IZ) of nonperfused and perfused spleens in three species of primitive mammals (shrew, mole, platypus) was studied morphologically. The IZ is a tissue zone consisting of plexiform vessels, probably venous capillaries, and is located transitionally between the white and red pulp. The IZ is separated from the white pulp by the arterial net (AN), in which the white pulp arteries terminate. Development of the IZ differs between the three species examined being distinctive in the platypus and shrew. The IZ is thin in the mole spleen. A closed type of arteriovenous (A-V) anastomosis was demonstrated in or around the IZ in the two Insectivora species examined. In the shrew spleen, peripheral arterial branches running within the IZ anastomose with the AN around the follicle. The AN anastomoses eventually with venous plexiform vessels of the IZ around the nonfollicular area of the white pulp to form a closed system. In the mole spleen, A-V anastomoses were noted between white pulp arteries (follicular and AN) and veins of the red pulp, either by direct communication or through fenestrated IZ vessels compatible with the plexiform vessels of the shrew spleen. A-V anastomosis in the IZ is probable, but not confirmed, in the platypus spleen, as analysis was limited to a nonperfused specimen. Well-developed ellipsoids were noted around arterial terminals of the IZ in the shrew spleen. Ellipsoids were also noted around all arterial terminals of the mole spleen directed to the red pulp. Most ellipsoids of the mole spleen appeared located within the IZ. No ellipsoids were present around arterial terminals of the IZ in the platypus spleen. Closed circulation was noted in terminals of the pulp artery in spleens of all three species. All pulp arteries of the mole spleen are postellipsoid segments of white pulp (AN and follicle) arteries. No ellipsoids were found around terminals of the pulp artery (penicillar artery) in shrew and platypus spleens. The IZ is probably homologous to the perilymphatic sinusoid (vein) of the lungfish spleen and may be regarded as part of the red pulp. The IZ may be representative of primitive mammalian spleens that have closed circulation. The marginal zone (MZ) of common mammalian spleens is probably a modified IZ by differentiation (remodelling) of the intrasplenic vein. In this process, withdrawal of venous vessels from the IZ occurred, leaving a lymphoreticular zone with open circulation (MZ). The marginal sinus reported in some mammalian spleens is probably a modified AN formed during this process. Possible morphological alterations of the spleen in vertebrate phylogeny are discussed.

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