Splenic preservation: an additional haemostatic measure during mesh splenorrhaphy

Reddy, Chaitan; Chalasani, Venu; Pathma‐Nathan, Nimalan

doi:10.1111/j.1445-2197.2004.03065.x

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…Poly(lactic-co-glycolic) acid (PLGA) appears as an attractive candidate for the fabrication of microparticles since its use in resorbable sutures [13] for humans has been approved by the FDA. The protection that microparticles provide to the antigen and the improvement in the uptake by the antigen presenting cells (APC) result in the enhancement of the antigen poor immunogenicity [14].…”

Section: Introductionmentioning

confidence: 99%

Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology

Román

Irache

Gómez

et al. 2008

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Introductionmentioning

confidence: 99%

Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology

Román

Irache

Gómez

et al. 2008

European Journal of Pharmaceutics and Biopharmaceutics

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“…13 Although there was initial concern about infection, the Dexon mesh splenorrhaphy has been effectively used to control splenic bleeding due to intraoperative injury. 14,15 Topical application of hemostatic agents is one method of splenic preservation. 16,17 Canby-Hagino and colleagues reported the use of fibrin sealant in 2 patients: the first one underwent open and the second was laparoscopic left nephrectomy and both were complicated by splenic laceration.…”

Section: Discussionmentioning

confidence: 99%

Experience with sliding-clip splenorrhaphy for splenic injury during radical nephrectomy

Giri

Abdelrahman

Flood

2015

CUAJ

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Introduction: We report our experience with sliding-clip splenorrhaphy (SCS), a novel splenic conservation technique, for iatrogenic splenic injury (ISI) during a left radical nephrectomy (RN). We also reviewed the literature on ISI. Methods: We retrospectively reviewed data from patients who had RN between January 2005 and December 2013 at our institution. The technique used was similar to sliding-clip renorrhaphy. Our Medline literature identified articles containing "splenic injury during nephrectomy," "iatrogenic splenic injury." "iatrogenic splenectomy," and "splenorrhaphy." Our primary outcome measures included incidence of splenic injury and splenic conservation rate and splenectomy. Results: Among the 370 RN, 140 were left sided. ISI injury occurred in 6 left RN (incidence 1.6% for all nephrectomies, 4.2% for leftsided nephrectomies). All 6 cases had open procedure and for the left-sided procedure. Splenic conservation was attempted in 4 patients using SCS and 3 out of 4 were successfully repaired. Altogether 3 patients had splenectomy (incidence 0.8% for all nephrectomies, 2.1% for left-sided nephrectomies). Our literature review revealed that the incidence of iatrogenic splenectomy during left nephrectomy varies from 1.3% to 13.2%. Conclusions: SCS is an acceptable novel splenic conservation technique due to its ease of use and success in selected patients with ISI. There is little evidence on the true incidence of ISI especially on splenic conservation during nephrectomy. Every attempt at splenic conservation is likely to improve immediate-and long-term patient outcomes.

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“…These can be applied to bleeding surfaces but are less effective in coaguloapthic models [30]. Oxycel, sutured into a polyglycolic acid mesh has been described to promote splenic salvage after injury [31]. This product has also been placed laparoscopically to control bleeding from a penetrating wound of the liver [32].…”

Section: Specific Product Adjuncts For Intraoperative Hemorrhage Controlmentioning

confidence: 99%

Biosurgicals and Trauma

Aucar¹,

Punja²,

Asensio³

2019

Biosurgicals - The Next Frontier in Operative Approaches [Working Title]

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Hemorrhage plays a prominent role in the outcome of trauma patients, from initial injury, through resuscitation, and stabilization. Biosurgicals have recently drawn attention to both the control of bleeding and chronic wound management. However, their role will be examined here in the context of adjuncts to control preoperative, intraoperative, and postoperative bleeding in trauma. A review of the scientific literature relevant to the use of passive and active topical hemostatic devices, as well as systemic pharmacologic agents, for control of hemorrhage is provided, in both military and civilian contexts. Bibliometric publication patterns and published guidelines are examined to identify the range of individual products available and the degree of attention they receive in the management of acute traumatic injuries. It is imperative that the evidentiary basis for the use of these agents be weighed against their cost and potential risks.

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Splenic preservation: an additional haemostatic measure during mesh splenorrhaphy

Abstract: In our experience this technique made the Dexon mesh bulkier and easier to secure as well as more haemostatic.

Cited by 9 publications

References 13 publications

Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology

Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology

Experience with sliding-clip splenorrhaphy for splenic injury during radical nephrectomy

Biosurgicals and Trauma

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