Splenic mast cell tumour and mastocytaemia in a cat: case study and literature review

Allan, Ross; Halsey, TR; Thompson, K. G.

doi:10.1080/00480169.2000.36176

Cited by 15 publications

(25 citation statements)

References 12 publications

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“…Splenic MCT is mainly a disease of older cats with no breed or sex predilection. The median age of cats in this study was 13 years, which is consistent with previously reported data . Additionally, most of the cats in this study were domestic breeds and males and females were equally distributed.…”

Section: Discussionsupporting

confidence: 91%

“…Splenic mast cell neoplasia is one of the most common splenic tumors in the cat, representing 15%‐27% of all splenic diseases in this species . Older cats are most often affected, with a mean age of 9‐13 years, and no breed or sex predilection has been reported …”

Section: Introductionmentioning

confidence: 99%

“…Although splenic MCT is one of the most common splenic diseases in the cat, it is still a relatively uncommon tumor and literature characterizing the disease is sparse, consisting mainly of small case reports and case series . A larger retrospective abstract was presented at a national conference several years ago, but this data was never published .…”

Section: Introductionmentioning

confidence: 99%

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Treatment outcomes and prognostic factors of feline splenic mast cell tumors: A multi‐institutional retrospective study of 64 cases

Evans

O'Brien

Allstadt³

et al. 2017

Vet Comparative Oncology

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Treatment outcomes and prognostic factors of feline splenic mast cell tumors: A multi‐institutional retrospective study of 64 cases

Evans

O'Brien

Allstadt³

et al. 2017

Vet Comparative Oncology

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“…Although mouse anti-human tryptase antibody has been used to detect mast cells in the small intestine from camels, 4 mast cell subtypes have not been adequately evaluated. Erythrophagocytosis and vacuolation in the mast cells noted in the current case have been reported 2,9,15 in both neoplastic and normal mast cells from several species, but the significance of this finding is unclear. According to the findings in the present case, it is also noteworthy that this antibody against KIT exhibits cross-reactivity with llama KIT and can be used to identify mast cells in this species.…”

mentioning

confidence: 62%

Mast Cell Tumors in a Llama (Lama Glama)

et al. 2010

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Abstract. A 9-year-old female llama (Lama glama) that served as a blood donor at The Ohio State University Veterinary Teaching Hospital developed multiple small, raised, firm, non-haired cutaneous masses on the right hip, left cheek, and right and left shoulders. Cytological evaluation of fine-needle aspirates from the cutaneous mass from the left shoulder and right hip comprised many well-differentiated, highly granulated mast cells with moderate numbers of eosinophils. Occasional mast cells exhibited erythrophagocytosis and contained a small amount of hemosiderin or several variably sized vacuoles. A cytologic diagnosis of mast cell tumor with evidence of prior hemorrhage was made, and the masses were surgically removed. Microscopically, each mass consisted of sheets of neoplastic round cells that formed nonencapsulated nodules in the dermis and infiltrated into the adjacent dermal collagen. Eosinophils were scattered among the mast cells at the periphery of the nodules. Neoplastic mast cells, but not eosinophils, exhibited positive membrane KIT expression and cytoplasmic vimentin staining. A final diagnosis of mast cell tumor was made based on cytology, histology, and immunohistochemistry.

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“…17 In cats, the only reported round cell neoplasia exhibiting erythrophagocytosis, to our knowledge, is mast cell disease. [18][19][20][21] The marked erythrophagocytosis by neoplastic T cells in this case is of clinical interest because this cat presented with a significant nonregenerative anemia and subsequent lethargy and weight loss.…”

Section: Discussionmentioning

confidence: 99%

Erythrophagocytic low‐grade extranodal T‐cell lymphoma in a cat

Carter

Tarigo

Vernau

et al. 2008

Veterinary Clinical Pathol

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A 13-year-old male castrated domestic shorthair cat was presented to the referring veterinarian with a 2-month history of weight loss and lethargy. Splenomegaly, hepatomegaly, nonregenerative anemia, neutropenia, and hyperbilirubinemia were noted. Results of testing for feline immunodeficiency virus, feline leukemia virus, Toxoplasma gondii, and Mycoplasma sp. were negative. On cytologic examination of aspirates from the enlarged spleen and liver, a population of erythrophagocytic round cells was observed. Splenectomy and a liver biopsy were done which revealed a population of CD3+/CD79a- erythrophagocytic mononuclear round cells localized in the hepatic and splenic sinusoids. T-cell PARR (PCR for antigen receptor gene rearrangements) analysis of bone marrow and spleen demonstrated a single band indicative of a clonal proliferation of T cells. Based on the marked splenomegaly, sinusoidal infiltration, lack of lymphadenopathy, and results of cytology, PARR, and immunophenotyping, a diagnosis of low-grade extranodal T-cell lymphoma was made. The cat was treated with chlorambucil and prednisolone; clinical and laboratory abnormalities resolved and the cat has remained clinically normal for 2.5 years. To our knowledge, this report documents the first case of an erythrophagocytic T-cell lymphoma in a cat. The clinicopathologic findings were suggestive of hepatosplenic T-cell lymphoma, a neoplasm described previously only in humans and dogs.

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Splenic mast cell tumour and mastocytaemia in a cat: case study and literature review

Abstract: Splenectomy and treatment with corticosteroids appears to have resulted in remission of clinical signs and anaemia. A reduction in the concentration of mast cells in the peripheral blood had not occurred 6 weeks postsplenectomy, but was evident by 10 months post-splenectomy.

Cited by 15 publications

References 12 publications

Treatment outcomes and prognostic factors of feline splenic mast cell tumors: A multi‐institutional retrospective study of 64 cases

Treatment outcomes and prognostic factors of feline splenic mast cell tumors: A multi‐institutional retrospective study of 64 cases

Mast Cell Tumors in a Llama (Lama Glama)

Erythrophagocytic low‐grade extranodal T‐cell lymphoma in a cat

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