Splenic marginal zone lymphocytes and related cells in the lymph node: A morphologic and immunohistochemical study

Krieken, J.H.J.M. van; Schilling, Christoph von; Kluin, Marieke; Lennert, K.

doi:10.1016/0046-8177(89)90040-3

Cited by 77 publications

(35 citation statements)

References 20 publications

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“…The cytology of human and mouse MZ cells appears to be very similar, as is the growth pattern. 8,11,24,25 The same is true for transformation into a higher-grade lymphoma 26,27 ; however, it appears to be less frequent in humans. By immunohistochemistry, both human and mouse MZLs are negative for both IgD and CD5 expression, but by flow cytometry, we found mouse MZLs to be IgD negative or dull positive and CD5 dull positive.…”

Section: Comparison Of Human and Mouse Marginal Zone Lymphomasmentioning

confidence: 81%

Splenic Marginal Zone Lymphomas of Mice

Fredrickson

Lennert

Chattopadhyay

et al. 1999

The American Journal of Pathology

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For nearly 100 years, it has been recognized that the lymph follicles of the spleen are limited by a lighter zone of lymphoid cells, 1 named the marginal zone (MZ) by Snook 2 in 1964. The lymphoid cells of the MZ are now considered by some to be memory B cells derived from recirculating precursors that migrate into germinal centers (GCs) when prompted by specific stimuli.3,4 After mutations of their immunoglobulin (Ig) genes, they reappear in the MZ and are apparently a reservoir of postfollicular memory B cells.

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Section: Comparison Of Human and Mouse Marginal Zone Lymphomasmentioning

confidence: 81%

Splenic Marginal Zone Lymphomas of Mice

Fredrickson

Lennert

Chattopadhyay

et al. 1999

The American Journal of Pathology

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“…6 Equivalent marginal zone cell populations have also been described in Peyer's patches, tonsilar intraepithelial crypt cells, palatine tonsils and the lymph nodes. [7][8][9][10] The investigation of B cell lineage and differentiation has been enormously facilitated by the discovery that B cells in the germinal center suffer somatic hypermutation of bcl-6 and immunoglobulin heavy chain variable region (IgV H ) genes, which in the case of Ig genes increases their affinity with the antigens present in the germinal center microenvironment. [11][12][13][14][15] Mutation analysis of rearranged IgV H genes in microdissected marginal zone B cells in the spleen, Peyer's patches and lymph nodes has shown that there are mutated IgV H genes in the majority of cells, as well as evidence of related B cell clones.…”

Section: Introductionmentioning

confidence: 99%

True

2001

Leukemia

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Splenic marginal zone lymphoma (SMZL) has been recognized as a distinctive type of small B cell lymphoma, and defined on the basis of its morphological, phenotypic, clinical and molecular characteristics. In spite of this, the borders of the entity, the homogeneity of the cases and the presumably cell origin of SMZL remain controversial issues. The frequency of mutation in the 5′ non-coding region of the bcl-6 gene has been used as a marker of germinal center derivation, which may be used to establish the molecular heterogeneity of different non-Hodgkin lymphoma (

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“…Later, these cells were demonstrated to express a B immunophenotype leading to calling them "monocytoid B-cells 8,13,14 . Monocytoid B-cells represent a peculiar type of small B-cell in rodents 15 and humans 9,13,16,17 .…”

Section: The Concept Of Mzmentioning

confidence: 99%

“…The MZ can also be observed in mucosa-associated lymphoid tissues (MALT), such as tonsils and Peyer's patches, in hyperplastic follicles arising in the gastrointestinal tract (follicular gastritis due to Helicobacter pylori infection), and in autoimmune disorders, such as thyroiditis or sialadenitis 6 . The MZ can occasionally be observed in lymph nodes, particularly in those draining MALT, such as the cervical lymph nodes draining the tonsils and the mesenteric lymph nodes 7,8 . The MZ has a pale perifollicular corona appearance due to the peculiar morphology of the lymphoid B-cells from which it is formed.…”

Section: The Concept Of Mzmentioning

confidence: 99%

Primary Splenic and Nodal Marginal Zone Lymphoma:

Diébold¹,

Tourneau²,

Compérat³

et al. 2005

J Clin Exp Hematopathol

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Primary splenic and nodal marginal zone (MZ) lymphomas are rare small B cell lymphomas presenting with similar histopathologic features. The neoplastic cell population mostly consists of monocytoid B cells organized in a MZ pattern, associated with centrocytoid cells colonizing follicles. About 50% of cases have a monotypic plasma cell component. The different histopathologic patterns and differential diagnosis are discussed here. Both diseases share a similar immunophenotype, with the expression of B-cell associated antigens and restriction of immunoglobulin light chain. The only difference is the more frequent expression of IgD in splenic than in nodal lymphomas. The most recent findings in genetics and molecular biology are presented and discussed. The main clinical and biological symptoms are described and the similarity of some cases with Waldenströms macroglobulinemia is stressed. Both lymphomas present with the same type of bone marrow involvement with a high frequency of intravascular infiltrates, which can be associated with interstitial and nodular infiltrates. Transformation into diffuse large B cell lymphoma occurs in about 10 to 15% of the cases. The outcome in many splenic MZ lymphomas is characterized by a lengthy survival after splenectomy (9 to 13 years or longer), despite the absence of a consensus on the optimal treatment. Nodal MZ lymphoma has a more aggressive evolution and seems to only be curable at an early stage. Further studies are needed of both lymphomas to improve treatment and prognosis.

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Splenic marginal zone lymphocytes and related cells in the lymph node: A morphologic and immunohistochemical study

Cited by 77 publications

References 20 publications

Splenic Marginal Zone Lymphomas of Mice

Splenic Marginal Zone Lymphomas of Mice

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Primary Splenic and Nodal Marginal Zone Lymphoma:

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