Splenic macrophages in preterm infants: a necropsy study.

Variend, S.; Drummond, Alvin C.; Coombs, R.R.A.

doi:10.1136/jcp.49.5.391

Cited by 2 publications

(2 citation statements)

References 22 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Macrophages play an important role in regulating erythropoiesis, cellular differentiation, and breakdown of cellular debris of aged cells. It is common to find increased macrophages and pigmented macrophages in the spleen during fetal development and in preterm infants (29,32). Pigmented splenic macrophages can be caused by melanin, hemosiderin, ceroid/ lipofuscin accumulation from the breakdown of cellular debris from aged or damaged cells (33).…”

Section: Discussionmentioning

confidence: 99%

Splenic development and injury in premature lambs supported by the artificial placenta

McLeod

Church

Coughlin

et al. 2019

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Introduction-The purpose of this study is to evaluate splenic effects during artificial placenta (AP) support. (118-121d, n=14) were delivered and placed on the AP support for a goal of 10-14 days. Cannulation used right jugular drainage and umbilical vein reinfusion. Early (ETC; 115-120d; n=7) and late (LTC; 125-131d; n=7) tissue controls were delivered and immediately sacrificed. Spleens were formalin fixed, H&E stained, and graded for injury, response to inflammation, and extramedullary hematopoiesis (EMH). CD68 and CD163 stains were used to assess for macrophage activation and density. Clinical variables were correlated with splenic scores. Groups were compared using Fisher's Exact Test and descriptive statistics. P<0.05 indicated significance. Methods-AP lambsResults-Mean survival for AP lambs was 12±5d. There was no necrosis found in any of the groups. Vascular congestion and sinusoidal histiocytosis did not significantly differ between AP and control groups (p=0.72; p=0.311). There were significantly more pigmented macrophages

show abstract

Section: Discussionmentioning

confidence: 99%

Splenic development and injury in premature lambs supported by the artificial placenta

McLeod

Church

Coughlin

et al. 2019

Journal of Pediatric Surgery

View full text Add to dashboard Cite

show abstract

“…Fatty changes in the spleen were reported as part of the Bsyndrome of sea-blue histiocytes,t hrombocytopenic purpura, and also in preterm infants fed with intravenous intralipid. Anemia, thrombocytopenia, cirrhosis, and possible propensity for infections were described in these syndromes [25][26][27]. Our literature review failed to find any report of splenic histiocytes accompanying surgical interventions.…”

Section: Discussionmentioning

confidence: 99%