Splenic infarction due to transient antiphospholipid antibodies induced by acute Epstein-Barr virus infection

Hal, Sebastiaan J. van; Senanayake, Sanjaya; Hardiman, Robyn

doi:10.1016/j.jcv.2004.07.013

Cited by 56 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this case, acute EBV infection may have induced increasing hemolysis and provoked the patient's initial symptoms. However, EBVinduced antiphospholipid antibodies, as described by van Hal et al, could not be detected in our patient [20].…”

Section: Discussioncontrasting

confidence: 55%

“…Infectious mononucleosis (IM) often begins with malaise, headache and low-grade fever before the development of the more specific signs of pharyngitis, cervical lymph node enlargement and moderate to high fever [16]. One case of splenic infarction during acute EBV infection associated with transient induction of antiphospholipid antibodies has recently been reported [20]. We did not find lupus anticoagulant in our patient, but protein C activity and antigen levels were reduced and currently remain low during follow-up.…”

Section: Discussionmentioning

confidence: 44%

See 1 more Smart Citation

Splenic infarction in a patient hereditary spherocytosis, protein C deficiency and acute infectious mononucleosis

et al. 2008

View full text Add to dashboard Cite

Splenic infarction is a common cause of left upper quadrant pain and must be suspected in patients with hematologic or thromboembolic conditions and signs of localized or systemic inflammation. Although several mechanisms have been proposed for splenic infarction in patients with various hematologic disorders, hereditary spherocytosis (HS) is usually not associated with an increased risk for thromboembolic events. We report a 13-year-old male with HS who was referred to our hospital with a 4-day history of fever and left upper quadrant pain. Ultrasound scans and magnetic resonance imaging showed lesions suggestive of splenic infarction. Initially, antibiotic treatment was started because secondary infection was suspected. However, 1 week after admission the patient developed typical clinical signs of acute infectious mononucleosis. Further laboratory work up confirmed the diagnosis of acute Epstein-Barr virus infection and additionally revealed protein C deficiency. This association has not been reported previously and may have contributed to the development of splenic infarction. Since infectious mononucleosis is a common cause for clinical consultations in adolescence, physicians caring for children with hematologic disorders should be particularly aware of those possible complications.

show abstract

Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 44%

Splenic infarction in a patient hereditary spherocytosis, protein C deficiency and acute infectious mononucleosis

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Of the 19 cases, six underwent follow up imaging with ultrasound and a CT scan was done in three cases each with follow-up ranging from 30 to 120 days [11,14,15]. All cases showed improvement.…”

Section: Discussionmentioning

confidence: 99%

Splenic infarct in a patient with Infectious Mononucleosis: a rare presentation

Noor

Sadough²,

Chan

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

View full text Add to dashboard Cite

show abstract

“…[8] During acute Q fever, IgG aCL are more frequent than lupus anticoagulant and IgM anticardiolipin antibodies, whereas anti-β2glycoprotein I antibodies are very rare. [3,9] However, “infectious” aCL, which are generally β2-glycoproetin I independent, were believed to be found in conditions not involving thrombotic complications, [7] whereas antiphospholipid-associated thrombosis during infections has been reported with Mycoplasma pneumoniae, [10–13] Bacteroides, [14] EBV, [15] CMV, [16,17] HIV, [18,19] HBV, [20] and HCV. [21] …”

Section: Introductionmentioning

confidence: 99%