Splenic hypofunction in patients with an incidental finding of small-sized spleen at abdominal ultrasound

Sabatino, Antonio Di; Maffè, Gabriella Carnevale; Brunetti, Laura; Guerci, M.

doi:10.1007/s11739-012-0869-7

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…Hyposplenism may be defined by low IgM memory B-cells as well as increased pitted red cells (> 4%) and Howell-Jolly bodies, which are consequences of a defective spleen filtering function of erythrocytes [ 27 ]. However, given the difficulty to test such parameters, abdominal ultrasound is a valid substitute, because of the existing association between a small spleen (< 7–8 cm) and reduced splenic function [ 28 ]. Nevertheless, today there are no guidelines supporting physicians to evaluate the splenic function systematically in CeD patients, due to data inconclusiveness.…”

Section: Factors Promoting Infection Susceptibility In Celiac Patientmentioning

confidence: 99%

How to manage celiac disease and gluten-free diet during the COVID-19 era: proposals from a tertiary referral center in a high-incidence scenario

et al. 2020

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The outbreak of COVID-19 and SARS-CoV-2 infection is spreading worldwide as the first coronavirus pandemic. The clinical picture is variable but flu-like symptoms are common with bilateral interstitial pneumonia being the most frightening presentation. No specific therapies nor vaccine have been developed to date and the only way to limit the virus diffusion is by modifying one’s lifestyle limiting social life and following strict hygienic precautions. No data is available on the risk of COVID-19 and its outcomes in celiac disease (CeD). The restrictions applied to counter COVID-19 can impact on CeD treatment and gluten-free dieting, the only available therapy for CeD. With the present manuscript, we aim to support gastroenterologists and nutritionists in the management of CeD patients in the new pandemic scenario, being conscious that availability and local situations are extremely various.

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Section: Factors Promoting Infection Susceptibility In Celiac Patientmentioning

confidence: 99%

How to manage celiac disease and gluten-free diet during the COVID-19 era: proposals from a tertiary referral center in a high-incidence scenario

et al. 2020

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“…In 66/128 (66 %) diesen so definierten morphologischen Hyposplenien konnten "pitted" Erythrozyten (pE) als Hinweis auf eine funktionelle Hyposplenie nachgewiesen werden. In allen Fällen dieser Studie lagen klinische Diagnosen mit dem Risiko zur Entwicklung einer funktionellen Hypoplasie/Aplasie vor [40] (▶ Tab. 1).…”

Section: Merkeunclassified

“…Gesichert werden kann der Funktionsverlust der Milz über die fehlende Darstellung des Organs in der TSZ und dem Nachweis von HJB/PE. Sabatino et al [40] fanden in einer Ultraschallstudie bei 4585 Patienten*innen in 4,4 % eine kleine Milz definiert durch eine Länge < 8 cm bei Männern und < 7,5 cm bei Frauen. In 66/128 (66 %) diesen so definierten morphologischen Hyposplenien konnten "pitted" Erythrozyten (pE) als Hinweis auf eine funktionelle Hyposplenie nachgewiesen werden.…”

Section: Merkeunclassified

„Hyposplenie“, eine weitgehend unerkannte Immunschwäche: Ist die Sonografie hilfreich?

et al. 2022

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ZusammenfassungDas Immundefizienzsyndrom der funktionellen Hyposplenie/Asplenie ist weitgehend unerkannt. Die Goldstandardprozedur stellt die Technetium-99m-Szintigrafie von hitzedenaturierten Erythrozyten (TSZ) sowie der Nachweis von pitted Erythrozyten oder Howell-Jolly-Körperchen (HJB) dar. Erste Arbeiten weisen darauf hin, dass dieses Krankheitsbild mit einer kleinen Milz assoziiert ist. Ziel der vorliegenden Übersicht ist es, den Stellenwert der B-Bild-Sonografie und der kontrastunterstützten Sonografie bei der Immunschwäche der Hyposplenie darzustellen.

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“…In addition to the presence of low IgM memory B cells, increased pitted red blood cells, and Howell-Joly bodies, simple evaluation of spleen size and volume by abdominal ultrasound can be considered the first step in detecting hyposplenism. In this context, Di Sabatino et al showed that two-thirds of individuals with a small spleen (longitudinal diameter <7.5-8 cm, incidentally detected on abdominal ultrasound) had splenic hypofunction, with pitted erythrocyte levels comparable to those of splenectomized patients [13].…”

Section: Hyposplenism and Infections In CDmentioning

confidence: 99%

Pneumococcal vaccination in celiac disease

Casella¹,

Ingravalle²,

Abbate³

et al. 2019

Expert Review of Gastroenterology & Hepatology

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Introduction: Celiac disease (CD) is an immune-mediated disorder associated with gluten exposure in genetically predisposed subjects. Areas covered: Infectious disease is one of the causes of morbidity and mortality in CD patients. Invasive streptococcus pneumoniae (pneumococcus) is a particularly dangerous morbid condition in both the general population and celiac patients. Pneumococcal vaccination is the most effective means for its prevention. Expert opinion: In CD, evaluation of spleen function should be useful to select patients who may benefit from vaccination to reduce the risk of pneumococcal disease. Different strategies could be employed: physicians could search for signs of hyposplenism on peripheral blood smear or abdominal ultrasound. However, the best strategy to identify which patients will benefit from pneumococcal vaccination has not yet been defined.

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Splenic hypofunction in patients with an incidental finding of small-sized spleen at abdominal ultrasound

Cited by 7 publications

References 5 publications

How to manage celiac disease and gluten-free diet during the COVID-19 era: proposals from a tertiary referral center in a high-incidence scenario

How to manage celiac disease and gluten-free diet during the COVID-19 era: proposals from a tertiary referral center in a high-incidence scenario

„Hyposplenie“, eine weitgehend unerkannte Immunschwäche: Ist die Sonografie hilfreich?

Pneumococcal vaccination in celiac disease

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