2003
DOI: 10.1016/s0740-2570(03)00024-8
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Splenic histology and histopathology: an update

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Cited by 41 publications
(24 citation statements)
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“…If doubt persists, immunohistochemistry for neuroendocrine markers (chromogranin, synaptophysin, and CD56) and lymphoid markers (CD45) establishes the correct diagnosis in most cases. The presence of CD8-staining endothelial cells in the splenic sinuses, which is distinctive 39 can be used diagnostically to confirm the diagnosis of IPAS suspected on cytologic examination. 35 Another case of IPAS was similarly diagnosed as PEN based on the presence of chromogranin, glucagon, gastrin and somatostatin staining of fortuitously sampled pancreatic islet cells.…”
Section: Discussionmentioning
confidence: 99%
“…If doubt persists, immunohistochemistry for neuroendocrine markers (chromogranin, synaptophysin, and CD56) and lymphoid markers (CD45) establishes the correct diagnosis in most cases. The presence of CD8-staining endothelial cells in the splenic sinuses, which is distinctive 39 can be used diagnostically to confirm the diagnosis of IPAS suspected on cytologic examination. 35 Another case of IPAS was similarly diagnosed as PEN based on the presence of chromogranin, glucagon, gastrin and somatostatin staining of fortuitously sampled pancreatic islet cells.…”
Section: Discussionmentioning
confidence: 99%
“…The red pulp constitutes 80-95% of the spleen and performs processes such as blood filtration and removal of abnormal or aged blood cells. (van Krieken & te Velde, 1988;Kraus, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…Four patterns of splenic pathology were identified: erythroid extramedullary hematopoiesis with erythrophagocytosis, red pulp congestion with plasmacytosis, extramedullary hematopoiesis with red pulp congestion and dyserythropoiesis, and a chronic myelomonocytic leukemia pattern. Kraus 22 concluded that the cellular composition of myelodysplastic syndrome cannot be reliably distinguished from chronic myeloproliferative disorders based on histologic section. We found this to be generally true of all the neoplastic myeloid disorders included in the study, although there were some notable differences including marked eosinophilia in rare cases of chronic myelogenous leukemia, fibrosis and peritrabecular distribution in mastocytosis, increased numbers of immature cells in acute myeloid leukemia and the numerous atypical megakaryocytes seen in chronic idiopathic myelofibrosis.…”
Section: Discussionmentioning
confidence: 99%