Splenic Hematoma in Hb S‐β+thalassemia

Sickle Cell Beta-Plus Thalassemia with Subcapsular Hematoma of the Spleen

“…There have been a few reported cases of spontaneous rupture of spleen in patients with sickle cell disease and trait [ 23 , 24 ]. However, cases of sickle cell beta-plus thalassemia presenting with spontaneous splenic rupture and splenic hematoma has rarely been described before our case [ 25 ]. Mukhopadhyay et al described a similar case of splenic hematoma, which was possibly triggered by cocaine-induced vasospasm with acute splenic infarction and subsequent hemorrhage into the infarct.…”

Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively

“…42 Then the blood flow rate q ( t ) at the CCA could be calculated. Subsequently, the simplified Navier–Stokes equation 43,44 was used to establish a distributed parameter model of the circular tube similar to the CCA. Finally, the shear stress τ c ( t ) at the CCA endothelium under different pulsation frequency modes of the RBP could be expressed as follows:where a n stands for the Womersley number corresponding to the n th harmonic component, expressed as follows:where R is the inner diameter of the CCA, ρ is blood density, η is blood viscosity, Q ( ω n ) is the harmonic component of the macroscopic blood flow rate q ( t ) at the CCA, j is equal to the square root of −1, J 0 and J 1 represent the first class of zero-order and first-order Bessel functions, respectively, 45 and F 10 is expressed as follows:…”

“…42 Then the blood flow rate q(t) at the CCA could be calculated. Subsequently, the simplified Navier-Stokes equation 43,44 was used to establish a distributed parameter model of the circular tube similar to the CCA. Finally, the shear stress τ c (t) at the CCA endothelium under different pulsation frequency modes of the RBP could be expressed as follows:…”

Approaching the in vitro clinical trial: engineering organs on chips

“…PDMS, while a very useful material that has enabled the field of soft lithography since its genesis, suffers from a wide range of issues including its high stiffness and the transient nature of surface modifications which limit the length of time cells remain viable cultured on it. 31 Most problematic, however, is the absorption of proteins, drugs, and hydrophobic molecules into PDMS which complicates the PK/PD and accurate dosing of drugs. 32 The use of PDMS puts a significant limitation on the models we can achieve with OOCs.…”