Splenic Fine Needle Aspiration and Core Biopsy

Lal, Aseem; Ariga, Reshma; Gattuso, Paolo; Nemcek, Albert A.; Nayar, Ritu

doi:10.1159/000326667

Cited by 31 publications

(31 citation statements)

References 26 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other institutions have similarly reported a steady increase in the use of this procedure. 11,16,17 Over the 9-year range of this study, the majority of specimens (36/41) were obtained within the past 3 year. The primary reason for the procedure was assessment of metastatic malignancy to the spleen.…”

Section: Discussionmentioning

confidence: 99%

“…17 A list of diagnostic pitfalls identified in our study is illustrated in Table IV. In this study, the most common malignant neoplasm involving the spleen was lymphoma, which is consistent with previously reported studies. 5,11,14,17,20,21 In the largest multi-center study investigating splenic lesions, large cell lymphoma was the most common type of non-Hodgkin's lymphoma involving the spleen. 21 Similarly, large B-cell lymphoma was the most common type encountered in our institution.…”

Section: Discussionmentioning

confidence: 99%

“…11,15,27 A diagnosis of extramedullary hematopoesis was cytologically suggested in 2 cases diagnosed as granulomatous inflammation and splenic hamartoma.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9] Several studies in the literature report rare incidences of complications, including hemorrhage, pseudoaneurysm, and hypotension. 10,11 There is clear contraindication for the procedure such as hemorrhagic diathesis and infectious mononucleosis, 5 as well as clinical and laboratory safe-guards for the procedure. [1][2][3]12 There is no association between the number of passes and an increased risk of developing complications.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Friedlander

Wei

Iyengar

et al. 2008

Diagnostic Cytopathology

View full text Add to dashboard Cite

Fine needle aspiration (FNA) of the spleen is rarely performed, due to fear of procedure complications. The objective of this study is to review the cytologic diagnoses of aspiration biopsy of the spleen performed in a cancer center. Archival material (9-year period) was reviewed and correlated with histologic and ancillary test results, when available.Forty-one splenic FNA specimens were identified. There were no reported procedure complications. Nineteen cases were diagnosed as malignant. Of these, 11 were lymphomas. Nineteen cases were diagnosed as benign. There was one false-negative case and four false-positive cases. Primary splenic neoplasms were rare and misinterpreted as malignant. It is important to be familiar with the normal cytology of this uncommonly aspirated organ in order to successfully identify neoplastic and malignant processes. The use of ancillary studies is important in the definitive classification of benign and malignant splenic lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…11,15,27 A diagnosis of extramedullary hematopoesis was cytologically suggested in 2 cases diagnosed as granulomatous inflammation and splenic hamartoma.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Friedlander

Wei

Iyengar

et al. 2008

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…Both sFNA and sCB are safe for patients with splenomegaly, and certain studies reported they exhibit excellent diagnostic accuracy in splenic malignancies, but a relatively low efficiency in splenic lymphoma (34,35). However, other studies indicated they have a rather low diagnostic yield on account of inadequate specimenin addition, in a review of 49 cases there was an overall complication rate of 16%, and complications such as bleeding and splenic rupture may have a fatal outcome (36,37). In patients with diffuse malignant diseases involving the spleen, splenic puncture may increase the risk of hemorrhage or rupture (38).…”

Section: Discussionmentioning

confidence: 99%

Fever of unknown origin revealed to be primary splenic lymphoma: A rare case report with review of the literature

Sun

Cheng

Wang

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Fever is a common clinical presentation of a number of diseases. A sustained unexplained fever >38.3˚C lasting for >3 weeks without an established diagnosis despite intensive diagnostic evaluation is referred to as fever of unknown origin (FUO). FUO remains a clinical challenge for physicians, as it may be attributed to a wide range of disorders, mainly infections, malignancies, non-infectious inflammatory diseases and miscellaneous diseases. We herein report the case of a 59-year-old male patient who presented with prolonged unexplained fever and was found to have a diffusely enlarged hypermetabolic spleen, as shown on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography examination. Following splenectomy, histopathological examination revealed primary splenic lymphoma (PSL) of B-cell origin. The patient received 6 courses of systemic chemotherapy with rituximab, etoposide, cyclophosphamide, doxorubicin, vincristine and prednisone (R-ECHOP regimen) and responded well to treatment. Thus, in patients with FUO and splenomegaly, the possibility of PSL should be taken into consideration. IntroductionThe term ʻfever of unknown originʼ (FUO) was first introduced by Petersdorf and Beeson in 1961 based on an analysis of 100 cases, and it was defined as recurrent fever >38.3˚C, lasting for >3 weeks, remaining undiagnosed after 1 week of in-hospital evaluation (1). Several decades later, the criteria of FUO diagnosis have changed and it is currently defined by lack of a definitive diagnosis after appropriate inpatient or outpatient evaluation (2). In view of the patient's clinical circumstances and underlying immune status, FUO was categorized into classic, nosocomial, neutropenic and human immunodeffiency virus (HIV)-associated FUO by Durack and Street in 1991 (3). The etiologies of classic FUO mainly include infections, malignancies, non-infectious inflammatory diseases and miscellaneous causes, while some cases remain undiagnosed (4,5).Primary splenic lymphoma (PSL) is a rare malignant lymphoma with an incidence of ~1% among patients with non-Hodgkin lymphoma (NHL) (6), although the spleen is involved in approximately half of the cases of Hodgkin's disease and one-third of NHLs as part of systemic disease (7,8). Dasgupta et al (9) strictly defined PSL as lymphoma originating in the spleen and limited to the spleen and splenic hilum, without invasion of other sites, with an interval of ≥6 months prior to the appearance of lymphoma elsewhere.We herein present the case of a 59-year-old male patient with diffuse large B-cell PSL, who only exhibited sustained fever, without other remarkable complaints. To investigate the cause of the FUO, fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG-PET/CT) examination was performed and revealed a diffusely enlarged hypermetabolic spleen. Following diagnostic splenectomy, the histopathological diagnosis was diffuse large B-cell primary splenic NHL. Case reportA 59-year-old male patient presented with a history of fe...

show abstract

Fine-needle aspiration biopsy for the primary diagnosis of lymphoproliferative disorders involving the spleen: One institution's experience and review of the literature

et al. 2006

View full text Add to dashboard Cite

We report the fine-needle aspiration (FNA) biopsy findings for the primary diagnosis of lymphoproliferative disorders involving the spleen. We analyzed six cases of primary diagnosed lymphoma involving the spleen and out of these cases, identified one case of primary splenic lymphoma. We explore the potential pitfalls and difficulties encountered in making a primary diagnosis of lymphoma involving the spleen and how the preparation of the specimen for flow cytometric studies and/or cell block for immunohistochemical analysis can greatly aid in making a definitive diagnosis. To the best of our knowledge, this is the first report of T-cell rich B-cell subtype of diffuse large B-cell lymphoma and only the second report of primary splenic lymphoma of the spleen diagnosed by FNA biopsy. An extensive review and analysis of the literature involving FNA biopsy of the spleen is also discussed.

show abstract

Splenic Fine Needle Aspiration and Core Biopsy

Cited by 31 publications

References 26 publications

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen

Fever of unknown origin revealed to be primary splenic lymphoma: A rare case report with review of the literature

Fine-needle aspiration biopsy for the primary diagnosis of lymphoproliferative disorders involving the spleen: One institution's experience and review of the literature

Contact Info

Product

Resources

About