Splenic Destruction of Rh‐Sensitized, and of Heated Red Cells

Lymphoreticular dysfunction in idiopathic steatorrhoea.

“…The finding in some of the reported cases with splenic atrophy of greater numbers of Howell-Jolly bodies than occur after splenectomy (Boveri, 1942;Waldenstrom, 1947), and Crome and Mollison's (1964) finding in one patient with idiopathic steatorrhoea and atrophy of a heat-damaged red cell survival time greater than that occurring in patients after splenectomy suggests that lymphoreticular atrophy was present in some of the reported patients, although not commented on. Splenic atrophy appears to be unusual under the age of 30 years, and two reports only are available in which the presence of small spleens at necropsy on children with coeliac disease was noted (Meyer, 1932;Macrea and Morris, 1931).…”

The Use of 51Cr‐Labelled Heat‐Damaged Red Cells to Study Splenic Function

“…Wagner et al (1962) reported a case of sickle-cell anaemia with a decreased rate of clearance and diminished splenic uptake. Crome and Mollison (1964) found slower clearance rates in two patients, one of whom had sicklecell disease and the other idiopathic steatorrhoea. They suggested that the injection of either rhesus-antibody-sensitized or heated red cells might be useful in demonstrating the absence of functioning splenic tissue.…”

Intense Exercise Increases Protein Oxidation in Spleen and Liver of Mice

“…Additionally, we consider that the destroyed red blood cells were processed in the liver immediately after the intense exercise, while in the spleen, they were processed the day after exercise. It is known that the spleen and liver have a different erythrocyte capture mechanism due to differences in vessel construction 33,34. In fact, while red blood cells are trapped in the spleen when the level of impairment is low, red blood cells are only trapped in the liver when impairment is marked.…”