Splenic complications in pediatric sickle cell disease: A retrospective cohort review
Alex George,
Shannon E. Conneely,
Ross Mangum
et al.
Abstract:ObjectiveTo delineate the natural history of splenic complications other than loss of splenic function in children with sickle cell disease (SCD), we performed a retrospective chart review of patients with SCD treated at the Texas Children's Hospital.MethodsWe determined the dates of diagnoses of splenic complications, the number of acute splenic sequestration crises (ASSC), and hydroxyurea treatment in pediatric patients with SCD. We also examined the association of hydroxyurea therapy with the onset and seve… Show more
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