Splenic Complications in Pediatric Sickle Cell Disease: A Retrospective Cohort Review
Alex George,
Shannon E. Conneely,
Ross Mangum
et al.
Abstract:Objective: To delineate the natural history of splenic
complications other than the loss of splenic function in children with
sickle cell disease (SCD), we performed a retrospective chart review of
patients with SCD treated at the Texas Children’s Hospital.
Methods: We determined the dates of diagnoses of splenic
complications, the number of ASSC events, and hydroxyurea treatment in
patients with SCD. We also examined the association of hydroxyurea
therapy with the onset and severity of ASSC. Results: The
cumu… Show more
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