Splenic abscess with Clostridium novyi bacteraemia and sepsis

Wg, Vleminckx; Mw, Diltoer; Hd, Spapen; Piérard, Denis; J, De Mey; Gr, Delvaux; Lp, Huyghens

doi:10.1097/00042737-199703000-00016

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Cited by 7 publications

(2 citation statements)

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“…There is only 1 reported case of C novyi type A septicemia and splenic abscess without gas gangrene in humans. 13 Despite aggressive therapy, includ-…”

mentioning

confidence: 99%

Clostridium novyi Type A Intra‐abdominal Abscess in a Horse

Aleman

Watson

Jang

2003

Veterinary Internal Medicne

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“…There is only 1 reported case of C novyi type A septicemia and splenic abscess without gas gangrene in humans. 13 Despite aggressive therapy, includ-…”

mentioning

confidence: 99%

Clostridium novyi Type A Intra‐abdominal Abscess in a Horse

Aleman

Watson

Jang

2003

Veterinary Internal Medicne

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“…Type A and B cause gas gangrene in man and animals, while type B and D are responsible for other diseases in animals (2). Until the outbreak among intravenous drug users in 2000, infection with C. novyi had been extremely rare (2,3), with most isolates reported from infected war wounds. The rarity of infection by this organism has been confirmed by the incidence rate of reported human infections in Scotland of <1 per year (4).…”

Section: Discussionmentioning

confidence: 99%

Severe sepsis following wound infection by an unusual organism -Clostridium novyi

Majumdar

Woodcock

Cheesbrough

2004

International Journal of Clinical Practice

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We present a case of post-operative wound infection with Clostridium novyi in a non-intravenous drug user. Clinical features included progressive cellulitis despite being on antibiotics, accompanied by hypotension, marked leucocytosis and oedema but minimal fever. While established infection with this organism is associated with high mortality, our patient survived. The administration of clindamycin and intravenous immunoglobulin in addition to early surgical assessment and aggressive debridement of affected tissue may have contributed to this successful outcome. To our knowledge, this is the only reported post-operative wound infection due to this pathogen.

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