Splenectomy protects the kidneys against ischemic reperfusion injury in the rat

Hiroyoshi, Toshiya; Tsuchida, Masahiro; Uchiyama, Koichi; Fujikawa, Koki; Komatsu, Takahiro; Kanaoka, Yoshihiro; Matsuyama, Hideyasu

doi:10.1016/j.trim.2012.03.005

Cited by 19 publications

(17 citation statements)

References 27 publications

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“…Hiroyoshi et al, in an experimental model of renal IRI in the rat, confirmed better kidney function when 30-minute ischemia was followed by spleen removal. However, the post-ischemic observation was limited to just 24 hours [11]. This outcome is consistent with clinical observation of shortening of the delay in renal graft function in splenectomized recipients of cadaveric donor kidneys [12].…”

Section: Discussionsupporting

confidence: 84%

Splenectomy Attenuates the Course of Kidney Ischemia-Reperfusion Injury in Rats

Wystrychowski¹,

Filipczyk²,

Cierpka³

et al. 2014

Transplantation Proceedings

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Section: Discussionsupporting

confidence: 84%

Splenectomy Attenuates the Course of Kidney Ischemia-Reperfusion Injury in Rats

Wystrychowski¹,

Filipczyk²,

Cierpka³

et al. 2014

Transplantation Proceedings

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“…The spleen is a reservoir of monocytes that localize to infarcted tissue. 53 Other data suggest that splenectomy prevents IRI in rats 54 and the spleen plays a deleterious role in animal models of stroke. 55,56 These studies portray the spleen as a source of proinflammatory cells that propagate ischemic tissue injury.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway

Gigliotti

Huang

et al. 2013

Journal of the American Society of Nephrology

159

200

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AKI affects both quality of life and health care costs and is an independent risk factor for mortality. At present, there are few effective treatment options for AKI. Here, we describe a nonpharmacologic, noninvasive, ultrasound-based method to prevent renal ischemia-reperfusion injury in mice, which is a model for human AKI. We exposed anesthetized mice to an ultrasound protocol 24 hours before renal ischemia. After 24 hours of reperfusion, ultrasound-treated mice exhibited preserved kidney morphology and function compared with sham-treated mice. Ultrasound exposure before renal ischemia reduced the accumulation of CD11b + Ly6G high neutrophils and CD11b + F4/80 high myeloid cells in kidney tissue. Furthermore, splenectomy and adoptive transfer studies revealed that the spleen and CD4 + T cells mediated the protective effects of ultrasound. Last, blockade or genetic deficiency of the a7 nicotinic acetylcholine receptor abrogated the protective effect of ultrasound, suggesting the involvement of the cholinergic anti-inflammatory pathway. Taken together, these results suggest that an ultrasound-based treatment could have therapeutic potential for the prevention of AKI, possibly by stimulating a splenic anti-inflammatory pathway.

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“…[2][3][4][5][6][7][8][9]29 Splenic monocytes were activated and recruited to the infarct area in a mouse model of myocardial infarction 2 days after coronary artery ligation, an effect that was attenuated by SPX. 2 In agreement with those findings, in the present study, the number of macrophages infiltrating into the LA was reduced in rats of the AAC+SPX group on day 2.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 In other organs, SPX enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients, 5 and exerts a protective effect against ischemic reperfusion injury in the kidney. 6 On the other hand, it has been experimentally demonstrated that obesity resulting from a high-fat-diet (HFD) is associated with decreased serum level of interleukin (IL)-10 due to reduced secretion by the spleen. 7 Meanwhile, SPX also decreases the serum level of IL-10-a potent anti-inflammatory cytokine that is synthesized by multiple organs, including the spleen-and induces inflammation in several organs during the chronic phase.…”

Section: Introductionmentioning

confidence: 99%