Splenectomy prior to allogeneic hematopoietic SCT increases the risk of post-transplant lymphoproliferative disease

Splenectomy before allogeneic hematopoietic stem‐cell transplantation for myelofibrosis: Tumor burden matters!

“…3 Several retrospective studies indicate that splenectomized patients have faster post-transplantation granulocyte and platelet recovery than those not splenectomized. [4][5][6] However, splenectomy can be associated with significant morbidity and mortality due to bleeding, thrombosis, infectious complications and also an increased risk of post-transplant lymphoproliferative diseases 7 and graft vs host disease. 8 Overall, the available retrospective studies provide no clear This cohort of patients was followed out for subsequent outcomes used a multistate model with four states ("RFGM registration"; "splenectomy"; "death before allo-HCT", and "allo-HCT") to evaluate the association between splenectomy and the incidence of allo-HCT.…”