Splenectomy in Thrombopenic Purpura Hemorrhagica

Vincent, Beth

doi:10.1056/nejm192507301930501

Cited by 3 publications

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References 3 publications

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“…It is characterized by a diminution in the numiiiber of tho blood platelets, from the normal 250,000 to 40,000, 5,000, or lower, a normal coagulation time and a purolonged bleeding time often exceeding two hours (Dukes), and in tllo active stagre by some enlargement of the spleen. There aro various views as to the evil influence of the spleen in this condition, and as to tho mechanism of the good results of splenectomy introduced by Frank of Breslau in 1915, and followed by Kazielson of Prague (1917), Brill and Rosenthal (1923) in New York, B. Vincent (1925) in Boston, Cowen (1925) in Australia, and Sutherland and Williamson (1925) in London.…”

Section: Cases Associated With Changes In Thementioning

confidence: 99%

Diagnosis and Treatment of Splenic Enlargement in Children

Rolleston¹

1925

BMJ

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Section: Cases Associated With Changes In Thementioning

confidence: 99%

Diagnosis and Treatment of Splenic Enlargement in Children

Rolleston¹

1925

BMJ

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The results of splenectomy for purpura hæmorrhagica

Spence

1928

Journal of British Surgery

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HOUSE PHYSICIAN, RIhDICAL UNIT, BT. BARTHOLONEW'S HOSPITAL.Trm operation of splenectonip in the treatment of purpura hzniorrhagica was performed for t h e first time in 1916 by K a~n e l s o n ,~~ who argued t h a t the h;emorrhages were the result of the constant reduction in the number of blood platelets, or thrombocytes, and that this reduction was brought about by the destructive action of a diseascd spleen. He suggested the name ' thrornbocytolytic purpura '. Frank26 also advised splenectomy, but on different grounds-namely, t h a t the reduction in platelets was due to an inhibitory action of the spleen on the bonc-marrow, and for this reason called the disease 'essential thrombopcnia'. As pointed out by K~s t e r ,~~ experimental evidcncc favours Kaznclson's view : " 'iYere the platelets not formed in sufficicnt numbers, the amount of thromboplastic substance furnished t o the blood by their destruction would be insufficicnt t o cause prompt coagulation. Thc coagulation time, however, in this disease remains normal ".Following in the wakc of Frank and Kaznelson, many observers have. performed splenectomy in the treatment of purpura hzemorrhagica, and have reported good results accruing therefrom. It is thought advisable, thercfore, t o report the following two cases in which splenectomy was performed : tlie one, in which there was no recurrence of hzemorrhages a€ter a period of eight m o n t h ; the other, in which splenectomy had no effect on their occurrcnce.

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Discussion On The Diagnosis and Treatment of Splenic Enlargement in Children

Rolleston¹

1926

Proceedings of the Royal Society of Medicine

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Splenectomy in Thrombopenic Purpura Hemorrhagica

Cited by 3 publications

References 3 publications

Diagnosis and Treatment of Splenic Enlargement in Children

Diagnosis and Treatment of Splenic Enlargement in Children

The results of splenectomy for purpura hæmorrhagica

Discussion On The Diagnosis and Treatment of Splenic Enlargement in Children

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