Splenectomy for solitary splenic metastasis of ovarian cancer

Koh, Yang Seok; Kim, Jung Chul; Cho, Chol Kyoon

doi:10.1186/1471-2407-4-96

Cited by 36 publications

(39 citation statements)

References 18 publications

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“…The main patterns of splenic involvement include splenic artery, splenic vein and lymphatic dissemination (24). In the meantime, the low number of cases diagnosed with splenic metastases can be explained through multiple mechanisms, such as the tortuosity of the splenic artery, presence of splenic capsule, rhythmic contractions of the spleen, or through the antineoplastic properties of the splenic parenchyma (25).…”

Section: Case Reportmentioning

confidence: 99%

Solitary Splenic Metastasis Αfter Surgically-treated Cervical Cancer – A Case Report and Literature Review

Bacalbaşa

Bălescu

Marcu

et al. 2017

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Abstract. Background Cervical cancer remains one of the most common gynecologic malignancies worldwide; although association of oncologic treatment is widely performed, a number of cases will develop, at a certain moment, distant metastases (1, 2). Unfortunately, most patients in this situation will be diagnosed with disseminated secondary lesions, being candidates only for palliative treatment. In rare cases, solitary metastases have been reported, transforming the patient into the perfect candidate for re-operation. We present the case of a 31-year-old patient diagnosed with an isolated splenic recurrence 18 months after surgically-treated cervical cancer. Case ReportWe present the case of a 31-year-old patient who initially presented to our service for pelvic pain and massive vaginal bleeding. At that moment, a cervical biopsy revealed the presence of a moderately differentiated squamous cell cervical cancer. The preoperative investigations revealed a stage IIB cervical tumor, so the patient was submitted to neoadjuvant chemotherapy and radiation therapy followed by surgery; a total radical hysterectomy en bloc, with bilateral adnexectomy and pelvic lymph node dissection was performed. The histopathological studies confirmed the presence of an area of 5 mm with 4-mm deep invasion with malignant transformation; in the meantime, the histopathological evaluation of the lymph nodes revealed the absence of tumoral invasion in none of the retrieved lymph nodes (eleven left side lymph nodes and seven right side lymph nodes). These findings classified the lesion as a T1a2, pN0, M0 cervical cancer. At 18 months follow-up, the patient was diagnosed with an isolated tumoral mass of 5/5 cm located in the splenic hylum, so the patient was re-operated. Intraoperatively, the diagnostic of solitary splenic lesion was confirmed, so the patient was submitted to splenectomy (Figures 1-5). The postoperative course was uneventful, with the patient being discharged in the fifth postoperative day. The histopathological study revealed the presence of a 5/5 cm lesion with a typical aspect of a splenic metastasis of a moderately differentiated squamous cell cervical cancer. One month after discharge, the patient was submitted to adjuvant chemotherapy consisting of six cycles of cisplatin and paclitaxel. At one year follow-up, the patient is free of any recurrent disease or distant metastases. DiscussionCervical cancer has a high propensity of local spread, after destroying the natural compartmental borders, leading to the apparition of pelvic masses involving the urinary bladder and/or 2615

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Section: Case Reportmentioning

confidence: 99%

Solitary Splenic Metastasis Αfter Surgically-treated Cervical Cancer – A Case Report and Literature Review

Bacalbaşa

Bălescu

Marcu

et al. 2017

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“…1 Previous reports of patients undergoing splenectomies for malignant disease have identified ovarian cancer as the most common site of origin of metastatic splenic tumours. 2 A splenectomy is not infrequently required as part of a primary or secondary debulking procedure for epithelial cancer, and this is usually carried out in the context of peritoneal carcinomatosis. 3 Sonnendecker et al reported that 7.6% of their patients with advanced disease required splenectomy, and despite utilisation of prophylactic heparin, the risk of thrombocytosis and thrombosis remained significant.…”

Section: Discussionmentioning

confidence: 99%

Prolonged survival after laparoscopic splenectomy for recurrent ovarian cancer and no adjuvant therapy: a report and review of the literature

Marriqoun-Harris

Rhou

Storey

et al. 2013

Southern African Journal of Gynaecological Oncology

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“…Concerning tumor spread at primary diagnosis, advanced disease (FIGO Stage III-IV) was observed in 20 (57.1%) cases [6,27,32,34,35,36,37,38,40,41,42,45,] whereas early disease (FIGO Stage I-II) was observed in 9 (25.7%) [5,8,31,33,39,43,44] (unknown in 6 patients). Most cases of spleen recurrence were diagnosed by CT findings or elevated levels of serum CA125.…”

Section: Discussionmentioning

confidence: 99%

“…Searching the literature database (PubMed, Embase, Medscape) using the criteria of recurrence, solitary, splenic, ovarian cancer and tubal cancer and the references of retrieved articles, we found 35 cases of splenectomy for recurrent TOC (table 1) [5,6,8,26,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44]. Splenectomy was mainly part of secondary cytoreductive surgery and only in one case of tertiary cytoreduction [43].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Splenectomy as Quaternary Cytoreduction for Isolated Parenchymal Splenic Recurrence of Epitelial Tubo-Ovarian Cancer: Report of a Case and Literature Review

Sorbi¹,

Prosperi²,

Villanucci³

et al. 2015

Gynecol Obstet Invest

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Isolated parenchymal splenic lesions are very rare and may occur as recurrences in the form of epithelial tubo-ovarian cancer (ETOC). We report a case of solitary parenchymal splenic recurrence of ETOC, which developed 50 months after the initial treatment. A 66-year-old woman underwent laparotomic primary cytoreduction in 2008. After platinum-based chemotherapy, she developed recurrences; thus, she underwent secondary and tertiary cytoreduction in 2011 and 2012 respectively. In April 2013, CT scan documented a solitary parenchymal splenic lesion and it was confirmed by FDG PET/CT. She underwent quaternary cytoreduction by laparoscopic splenectomy. Histopathological evaluation revealed metastatic parenchymal disease consistent with recurrent ETOC. She was alive and disease-free for ten months since splenectomy. In literature there are 35 cases of isolated spleen parenchymal metastasis of ETOC and our report is the first case of laparoscopic splenectomy in the setting of quaternary cytoreduction. Laparoscopic splenectomy as quaternary cytoreduction is safe and feasible and could be congruent to the well-established experiences already reported for the primary, secondary or even tertiary cytoreduction where the absence of residual disease has been translated in a significant survival benefit.

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Splenectomy for solitary splenic metastasis of ovarian cancer

Cited by 36 publications

References 18 publications

Solitary Splenic Metastasis Αfter Surgically-treated Cervical Cancer – A Case Report and Literature Review

Solitary Splenic Metastasis Αfter Surgically-treated Cervical Cancer – A Case Report and Literature Review

Prolonged survival after laparoscopic splenectomy for recurrent ovarian cancer and no adjuvant therapy: a report and review of the literature

Laparoscopic Splenectomy as Quaternary Cytoreduction for Isolated Parenchymal Splenic Recurrence of Epitelial Tubo-Ovarian Cancer: Report of a Case and Literature Review

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