Splendore‐Hoeppli phenomenon in a fine needle aspirate of cervicofacial actinomycosis

Aragão, Alessa; Biemer, John; Barkan, Güliz A.; Pambuccian, Stefan E.

doi:10.1002/dc.24025

Cited by 5 publications

(12 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Aspergillus-infected tissues, similar to Entomophthorales, show an eosinophilic inflammatory infiltrate but also reveal Charcot-Leyden crystals. [8][9][10] Mucorales are more likely to be associated angioinvasion with thrombosis, and typically show a neutrophilic infiltrate. 4 Conidiobolomycosis, which is another species of Entomophthorales, is a cytomorphologic and histopathologic mimicker of Basidiobolomycosis, but it usually affects the rhinofacial and sinonasal regions in F I G U R E 7 (A) Growth of a yellow-white creamy waxy primary colony demonstrating a radial folded pattern and small secondary satellite colonies from the discharged germinating conidia in Sabouraud dextrose agar.…”

Section: Case Reportmentioning

confidence: 99%

ThinPrep liquid‐based cytologic diagnosis of hepatic entomophthoromycosis (basidiobolomycosis) with Splendore‐Hoeppli phenomenon

AbdullGaffar,

Keloth,

Al Marzouqi

2023

Diagnostic Cytopathology

View full text Add to dashboard Cite

Zygomycotic fungal infections are increasingly recognized in immunocompetent and immunocompromised patients in nonendemic countries because of the increased global travels. One of the emerging fungal infections is Entomophthorales which cause deep visceral infections that clinically and radiologically mimic malignancies because they form invasive obstructing masses. A quick diagnosis is life‐saving. The current standard diagnosis relies on histopathologic examination and microbiology culture which are time consuming. Cytologic examination is a rapid reliable alternative diagnostic tool. There are a few reports of a primary cytologic diagnosis of zygomycotic and Aspergillus fungi of the lungs based on conventional smear and SurePath™ liquid‐based cytology. We report a case of an immunocompetent adult female who presented with a liver mass that was clinically and radiologically diagnosed as cholangiocarcinoma. Fine‐needle aspiration cytology revealed the cytopathologic features of basidiobolomycosis in ThinPrep® cytology. The ThinPrep® slide revealed broad thin‐walled widely branching septate hyphae with sporangiophores and zygospores. The background revealed bile‐stained granular necrotic debris intermixed with inflammatory cells, degenerate hepatocytes, and highly eosinophilic glassy crystal‐like structures suggestive of Splendore‐Hoeppli phenomenon. The cytologic diagnosis was hepatic entomophthoromycosis (basidiobolomycosis) with Splendore‐Hoeppli phenomenon. This was confirmed by subsequent tissue biopsy and microbiology culture. The detailed cytomorphologic features in the ThinPrep® slide allowed the correct cytologic diagnosis and proper classification of the filamentous fungi. The ThinPrep® cytology was superior to tissue biopsy because it was faster and revealed the characteristic pauciseptate fungal hyphae, sporangiophores and zygospores. Liquid‐based cytology is a valuable quick tool in the diagnosis of fungal mass‐forming lesions.

show abstract

Section: Case Reportmentioning

confidence: 99%

ThinPrep liquid‐based cytologic diagnosis of hepatic entomophthoromycosis (basidiobolomycosis) with Splendore‐Hoeppli phenomenon

AbdullGaffar,

Keloth,

Al Marzouqi

2023

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…Histologically, they are clusters of suppurative and granulomatous infiltrates with associated bacteria. The granules can be surrounded by brightly eosinophilic areas (Splendore‐Hoeppli phenomenon) . Sulfur granules are not pathognomonic, as they are only present in 35–55% of cases and are also seen with Nocardia, Streptomyces, and Peptostreptococcus .…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

Cervicofacial actinomycosis

et al. 2020

View full text Add to dashboard Cite

Cervicofacial actinomycosis is an uncommon, chronic, suppurative, and granulomatous bacterial infection. It is often of dental origin and tends to mimic other dental infections, granulomatous disorders, and cancers. The initial diagnostic workup, predicated upon imaging and tissue biopsies, is frequently nonspecific. A definitive diagnosis is usually rendered only after surgical excision and histologic examination of the cervicofacial mass. We propose a classification of three stages: localized infection without sinus involvement, localized infection with sinus involvement, and disseminated infection, to facilitate recognition, diagnosis, and early aggressive treatment. Untreated infection may be lifethreatening. Therapy may require long-term antibiotics; however, many cases may also necessitate complete surgical excision.

show abstract

“…The SHP is usually observed in histological sections, although its presence in cytological samples has been rarely described 5‐7 . Descriptions about this phenomenon around microorganisms in pulmonary samples are also scarce in the literature 8 .…”

Section: Figurementioning

confidence: 99%

“…4 The SHP is usually observed in histological sections, although its presence in cytological samples has been rarely described. [5][6][7] Descriptions about this phenomenon around microorganisms in pulmonary samples are also scarce in the literature. 8 Herein, we report the case of a 67 year-old man, with a history of alcoholism and very poor dental hygiene who was admitted to the hospital because of fever, a productive cough, chest pain and asthenia for several months.…”

mentioning

confidence: 99%