Spleen Organoid Units Generate Functional Human and Mouse Tissue-Engineered Spleen in a Murine Model

Gee, Kristin M.; Isani, Mubina; Fode, Alexa; Maselli, Kathryn M.; Zuber, Samuel M.; Fowler, Kathryn L.; Squillaro, Anthony I.; Nucho, Laura-Marie A.; Grikscheit, Tracy C.

doi:10.1089/ten.tea.2019.0178

Cited by 2 publications

(1 citation statement)

References 25 publications

(31 reference statements)

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“…[ 20 ] Further study on splenic regeneration was conducted with both mouse‐ and human‐derived splenic units by implantation in NOD/severe combined immunodeficiency (SCID) mice and showed proliferative cells of the donor spleen. [ 21 ] It is worth noting that due to the complexity in immune responses, engineered devices were currently studied to mimic spleen. Ingber's group developed a biospleen which could clear infectious agents in the blood without identifying them.…”

Section: Engineered Immune Tissues and Organs For Immune Functionsmentioning

confidence: 99%

Tissue Engineering for Mimics and Modulations of Immune Functions

Tao

Wang

2021

Adv Healthcare Materials

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In the field of regenerative medicine, advances in tissue engineering have surpassed the reconstruction of individual tissues or organs and begun to work towards engineering systemic factors such as immune objects and functions. The immune system plays a crucial role in protecting and regulating systemic functions in the human body. Engineered immune tissues and organs have shown potential in recovering dysfunctions and aplasia of the immune system and the evasion from immune‐mediated inflammatory responses and rejection elicited by engineered implants from allogeneic or xenogeneic sources are also being pursued to facilitate clinical transplantation of tissue engineered grafts. Here, current progress in tissue engineering to mimic or modulate immune functions is reviewed and elaborated from two perspectives: 1) engineering of immune tissues and organs per se and 2) immune evasion of host immunoinflammatory rejection by tissue‐engineered implants.

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Section: Engineered Immune Tissues and Organs For Immune Functionsmentioning

confidence: 99%

Tissue Engineering for Mimics and Modulations of Immune Functions

Tao

Wang

2021

Adv Healthcare Materials

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Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm

Gabriel,

Zdyrski,

Sahoo

et al. 2024

IJMS

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Preclinical biomedical research is limited by the predictiveness of in vivo and in vitro models. While in vivo models offer the most complex system for experimentation, they are also limited by ethical, financial, and experimental constraints. In vitro models are simplified models that do not offer the same complexity as living animals but do offer financial affordability and more experimental freedom; therefore, they are commonly used. Traditional 2D cell lines cannot fully simulate the complexity of the epithelium of healthy organs and limit scientific progress. The One Health Initiative was established to consolidate human, animal, and environmental health while also tackling complex and multifactorial medical problems. Reverse translational research allows for the sharing of knowledge between clinical research in veterinary and human medicine. Recently, organoid technology has been developed to mimic the original organ’s epithelial microstructure and function more reliably. While human and murine organoids are available, numerous other organoids have been derived from traditional veterinary animals and exotic species in the last decade. With these additional organoid models, species previously excluded from in vitro research are becoming accessible, therefore unlocking potential translational and reverse translational applications of animals with unique adaptations that overcome common problems in veterinary and human medicine.

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Spleen Organoid Units Generate Functional Human and Mouse Tissue-Engineered Spleen in a Murine Model

Cited by 2 publications

References 25 publications

Tissue Engineering for Mimics and Modulations of Immune Functions

Tissue Engineering for Mimics and Modulations of Immune Functions

Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm

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