Splanchnic galactose uptake in patients with cirrhosis following single injection

Ranek, L; Lindskov, J; Tygstrup, Niels; Medical, Keaise

doi:10.1111/j.1475-097x.1983.tb00688.x

Cited by 13 publications

(7 citation statements)

References 7 publications

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“…GEC is known to be a good indicator of the prognosis particular in ALF. 18 It is interesting to note that extrapolation of the linear regression line in Fig. 4, left panel to Cl int/sorbitol equals zero results in GEC, equal to 9.8 µmol и kg Ϫ1 и min Ϫ1 (7.0 to 12.6, 95% confidence limits).…”

Section: Sorbitol As Test Substance For Estimation Of Hepatic Plasma mentioning

confidence: 91%

Hepatic plasma flow estimated according to fick’s principle in patients with hepatic encephalopathy: Evaluation of indocyanine green and d-sorbitol as test substances

1998

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Section: Sorbitol As Test Substance For Estimation Of Hepatic Plasma mentioning

confidence: 91%

Hepatic plasma flow estimated according to fick’s principle in patients with hepatic encephalopathy: Evaluation of indocyanine green and d-sorbitol as test substances

1998

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“…Vmax re flects the enzyme activity of galactokinase which assumes to be proportional to the over all residual liver function [12,16,17], How ever. hepatic blood flow plays a very impor tant role in the assessment of liver function [15].…”

Section: Discussionmentioning

confidence: 99%

“…The GEC was assessed largely according to Tygstrup's [ 18] procedure [12. 16] [17], A dupli cate. six-concentration calibration curve, ranging from 49.82 to 1.90!…”

Section: Methodsmentioning

confidence: 99%

“…The galactose blood concentration was measured by an enzymatic method [ 17], 50 pi of blood were col lected. using disposable microliter pipettes, then added to 0.5 ml EDO in a test tube kept on ice.…”

Section: Measurement O F Galactose Blood Concentrationmentioning

confidence: 99%

“…In the liver, galactose is catalyzed by galactokinase through epimerization, thus converting to glucose-1-phos phate. The reaction with galactokinase is the rate-limiting step of the galactose metabolism in the liver [11][12][13][14], Since galactose is a high extraction ratio compound, based on the 'well stir model', the clearance of the first order process at a low concentration can represent the hepatic blood flow [ 15], When a large amount of galactose is administered, galac tose metabolism can be saturated due to the limited capacity of galactokinase [12], In ani mals [16] and humans [17], galactose follows the Michaelis-Menten saturation kinetics. Therefore, Tygstrup [ 18] developed the galac tose elimination capacity (GEC) method to quantitatively estimate the liver function, i.e.…”

mentioning

confidence: 99%

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Assessment of Liver Function Using a Novel Galactose Single Point Method

Tang

1992

Digestion

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A novel, simple, clinically useful quantitative liver function test, called the galactose single point (GSP) method, was developed by measurement of galactose blood concentration 1 h after galactose was administered (0.5 g/kg). It was quickly infused intravenously in 55 normal healthy volunteers, 73 patients with chronic hepatitis (CH), 36 with cirrhosis and 41 with hepatocellular carcinoma (HCC). Patients with CH diagnosis were assessed by liver biopsy. Cirrhosis was diagnosed by histological examination or a chronic hepatitis history with esophageal varices or ascites, whereas HCC was diagnosed either histologically, or cytologically proved, or as implied in the ‘one imagine study’ being positive with AFP > 300 ng/dl. Highly significant galactose blood levels were observed between normal healthy volunteers and patients 50, 60 and 70 min after galactose was administered. Galactose elimination capacity (GEC), modified GEC (MGEC) and consecutive GSP tests were performed in 6 healthy volunteers for 2 days. 0.64-16.87% variation was observed for each subject. The significant differences (p < 0.001) in average GSP values were 247 ± 18.1, 422 ± 27.3, 629 ± 42.8 and 579 ± 43.6 µg/ml for normal healthy volunteers, CH, cirrhosis and HCC patients, respectively. Highly significant correlations (p < 0.001) were obtained among GSP, GEC and MGEC for all patients. Positive correlations were observed between GSP, GEC, MGEC and AST (serum aspartate aminotransferase), ALT (serum alanine aminotransferase), serum bilirubin, albumin, prothrombin time and r-globulin. According to results obtained from 202 normal healthy volunteers and patients, the GSP method may be a simple, clinically useful quantitative measurement of liver function for the determination of a patient’s residual liver function, the prognosis of liver function for patients with cirrhosis, postoperational follow-up and, finally, the timing of a liver transplant.

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The influence of chronic lobular hepatitis on pharmacokinetics of cefoperazone—a novel galactose single‐point method as a measure of residual liver function

Hu¹,

Tang

Chang³

1994

Biopharm & Drug Disp

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Cefoperazone is a semisynthetic cephalosporin antibiotic containing a piperazine side chain, which results in antipseudomonal activity. Unlike the other cephalosporins, it is mainly cleared by the liver (60-80%) and it may be more sensitive to changes in the liver function and/or plasma protein binding than other cephalosporins, which are not primarily cleared by the liver. In order to study the influence of chronic lobular hepatitis on the pharmacokinetics of cefoperazone, a dose of 1 g of cefoperazone was administered to 11 normal, healthy volunteers and 16 subjects with chronic lobular hepatitis. In each volunteer or patient, a novel galactose single-point (GSP) method, the galactose elimination capacity (GEC) test, and the modified galactose elimination capacity (MGEC) test were also performed as a measure of residual liver function. Cefoperazone was administered intravenously over a period of 3-5 min. Blood and urine samples were collected at appropriate intervals after drug administration and stored at -30 degrees C until high-pressure liquid chromatographic (HPLC) analysis. The cefoperazone hepatic clearance, mean residence time, and renal clearance in hepatitis patients were significantly different from those of normal healthy volunteers, whereas the plasma protein binding was unaltered between the two groups. Urinary excretion of cefoperazone showed a highly significant increase in patients, 23.95 +/- 5.06% and 37.54 +/- 13.61% for normal men and hepatitis patients respectively. Hepatic clearance and fraction excreted in urine significantly correlated with values of GSP and MGEC respectively (p < 0.05). These results suggest (i) cefoperazone kinetics was significantly altered in patients with chronic lobular hepatitis; (ii) GSP, a novel simple, clinically useful quantitative liver function test, can predict the cefoperazone hepatic clearance in patients with liver dysfunction.

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Splanchnic galactose uptake in patients with cirrhosis following single injection

Cited by 13 publications

References 7 publications

Hepatic plasma flow estimated according to fick’s principle in patients with hepatic encephalopathy: Evaluation of indocyanine green and d-sorbitol as test substances

Hepatic plasma flow estimated according to fick’s principle in patients with hepatic encephalopathy: Evaluation of indocyanine green and d-sorbitol as test substances

Assessment of Liver Function Using a Novel Galactose Single Point Method

The influence of chronic lobular hepatitis on pharmacokinetics of cefoperazone—a novel galactose single‐point method as a measure of residual liver function

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