Spitz nevi: diverse clinical, dermatoscopic and histopathological features in childhood

Dika, Emi; Neri, Iria; Fanti, Pier ­Alessandro; ­Barisani, Alessia; Ravaioli, Giulia Maria; Patrizi, Annalisa

doi:10.1111/ddg.12904

Cited by 5 publications

(8 citation statements)

References 19 publications

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“…Atypical Spitz nevi are associated with an irregular distribution of structures and colors. 3 Interestingly, Ghahramani et al reported a case of a 17-monthold girl with atypical Spitz nevus presenting as a dome-shaped red-to-yellow papule and showing the setting sun dermoscopic appearance of JXG. 4 However, vascular structures were polymorphous with scattered dotted, comma-like, and serpentine vessels.…”

mentioning

confidence: 99%

Is the setting sun dermoscopic pattern specific to juvenile xanthogranuloma?

Litaiem

Zéglaoui

2018

Journal of the American Academy of Dermatology

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mentioning

confidence: 99%

Is the setting sun dermoscopic pattern specific to juvenile xanthogranuloma?

Litaiem

Zéglaoui

2018

Journal of the American Academy of Dermatology

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“…thought to be underdiagnosed in Black patients. [5][6][7][8][9][10][11][12][13][14]17,18,[20][21][22][23][24][25][26][27][28][29][30][31][32] Some studies have focused on characterizing Spitz lesions in Hispanic and Black patients. 10,29 Incidence of SN in the predominantly Caucasian countries of the United States, Australia, and the United Kingdom has been reported as 7, 1.66, and 1.4 per 100,000 persons per year and as <1 in the predominantly Asian country Korea.…”

Section: Discussionmentioning

confidence: 99%

“…Fitzpatrick score was assessed by predisposition to burn or tan, and 74.5% of Spitz patients surveyed reported Type I‐III. Meta‐analysis suggests Spitz neoplasms most commonly occur in Caucasians; however, Spitz lesions have traditionally been studied in majority Caucasian cohorts and are thought to be underdiagnosed in Black patients 5‐14,17,18,20‐32 . Some studies have focused on characterizing Spitz lesions in Hispanic and Black patients 10,29 .…”

Section: Discussionmentioning

confidence: 99%

“…The data and literature suggest a slight predominance of spitzoid proliferation in females, with a ratio close to 1.4:1; however, this has been reported as high as 3:1, particularly after age 10–15 years. 6 , 7 , 10 , 12 , 18 , 20 , 21 , 22 , 23 , 24 …”

Section: Discussionmentioning

confidence: 99%

“…Meta‐analysis suggests Spitz neoplasms most commonly occur in Caucasians; however, Spitz lesions have traditionally been studied in majority Caucasian cohorts and are thought to be underdiagnosed in Black patients. 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 17 , 18 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 Some studies have focused on characterizing Spitz lesions in Hispanic and Black patients. 10 , 29 Incidence of SN in the predominantly Caucasian countries of the United States, Australia, and the United Kingdom has been reported as 7, 1.66, and 1.4 per 100,000 persons per year and as <1 in the predominantly Asian country Korea.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors for the development of Spitz neoplasms

Benton

Roth

Khan

et al. 2022

Pediatric Dermatology

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It is well recognized that Spitz neoplasms, though featuring histologic similarities to conventional melanoma cytologic atypia, confluent and expansile nesting, pagetoid spread, and mitotic activity, have distinct clinical and genomic characteristics compared to conventional nevi and melanomas, and the vast majority have indolent clinical behavior. 1 While most conventional nevi and melanomas are driven by UV-induced point mutations in genes such as BRAF or NRAS, many Spitz neoplasms are the result of chromosomal structural rearrangements in genes such as ALK, ROS1, NTRK1/3, BRAF, RET, and MAP3K8 among others, or harbor HRAS mutations, and these variants underlie the most recent WHO definition of Spitz neoplasms. [2][3][4] Overall, there are few studies investigating epidemiologic risk factors associated with the development of spitzoid neoplasms, hence risk factors for these tumors remain poorly understood, limiting clinical identification of patients more likely to develop spitzoid neoplasms. We constructed a patient survey focused on demographics, environmental exposures, medical history, and family history to investigate risk factors for Spitz neoplasms and performed a meta-analysis of relevant literature.

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The role of dermatoscopy in skin neoplasms diagnostics in children and adolescents

Кулева

Khabarova

2023

Pediatr (SPb)

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Information about the natural nevogenesis of pigmented skin lesions, evolutionary and morphological features in pediatric patients is still rare in the medical literature despite the progress in dermatooncology. Clinical examination or analysis with the naked eye of skin neoplasms carries a certain diagnostic information content. However, this method is much less informative compared to the use of an epiluminescent microscope. Dermoscopy of skin neoplasms is a non-invasive highly informative diagnostic method. Nowadays, the technique is widely used in the clinical practice of pediatric oncodermatologists. This painless diagnosis is ideal for a primary analysis of the morphological picture melanocytic or other skin neoplasms, malignancy risk assessment and determining the tactics of managing pediatric patients. The necessity for differential diagnosis the spectrum of skin neoplasms dictates a trend towards improving research methods and an age-adapted approach. The method of skin microscopy can be attributed to the methods of choice among those currently available. The history of method, diagnostic informativeness and detailed morphological characteristics of melanocytic skin neoplasms in children and adolescents are presented.

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Spitz nevi: diverse clinical, dermatoscopic and histopathological features in childhood

Abstract: Pigmented Spitz nevi were more common after 13 years of age. The study confirms other reports regarding the distribution of pigmentation patterns, and underlines the low number of atypical Spitz nevi in pediatric patients as well as their low recurrence rate during long-term follow-up.

Cited by 5 publications

References 19 publications

Is the setting sun dermoscopic pattern specific to juvenile xanthogranuloma?

Is the setting sun dermoscopic pattern specific to juvenile xanthogranuloma?

Risk factors for the development of Spitz neoplasms

The role of dermatoscopy in skin neoplasms diagnostics in children and adolescents

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