Spitz Melanocytic Tumors: A Fascinating 75-Year Journey

Chatzopoulos, Kyriakos; Syrnioti, Antonia; Linos, Konstantinos

doi:10.3390/genes15020195

Cited by 3 publications

(1 citation statement)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within this category of melanocytic lesions, there is a spectrum ranging from benign Spitz nevi to Spitzoid and Spitz melanoma, passing through intermediate lesions identified as "atypical Spitz tumors" or melanocytomas [3]. There are also related lesions that may represent variations in these three categories.…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Profile of Benign, Intermediate, and Malignant Spitz and Spitzoid Melanocytic Lesions

Giubellino,

He,

Munro

et al. 2024

Cancers

View full text Add to dashboard Cite

Spitz and Spitzoid lesions represent one of the most challenging melanocytic neoplasms in dermatopathology. Nosologic classification has been more recently improved by the discovery of novel molecular drivers, particularly translocations. In the current study, we aimed to use an unbiased approach to explore the gene expression profile of a group of melanocytic Spitz and Spitzoid melanocytic lesions ranging from benign lesions to melanoma, including intermediate lesions such as SPARK nevi and atypical Spitz tumors/melanocytomas. Using unsupervised analysis of gene expression data, we found some distinct hierarchical clusters of lesions, including groups characterized by ALK and NTRK translocations. Few non-ALK translocated tumors demonstrated increased ALK expression, confirmed by immunohistochemistry. Spitz tumors with overlapping features of dysplastic nevi, so-called SPARK nevi, appear to have a common gene expression profile by hierarchical clustering. Finally, weighted gene correlation network analysis identified gene modules variably regulated in subtypes of these cases. Thus, gene expression profiling of Spitz and Spitzoid lesions represents a viable instrument for the characterization of these lesions.

show abstract

Section: Introductionmentioning

confidence: 99%

Gene Expression Profile of Benign, Intermediate, and Malignant Spitz and Spitzoid Melanocytic Lesions

Giubellino,

He,

Munro

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

Nevi – when to refer

Shah,

Jahnke

2024

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of review Congenital melanocytic nevi (CMN) and acquired nevi are prevalent in pediatric populations, with distinct characteristics and management considerations. This chapter aims to equip pediatricians with knowledge to discern between benign and high-risk nevi, facilitating appropriate referrals and management within primary care settings. Risk factors associated with malignant melanoma (MM) underscore the importance of vigilant monitoring and early referral to dermatology for suspicious lesions. Recent findings Recent findings highlight the variability in CMN presentation and the evolving diagnostic strategies, emphasizing the need for multidisciplinary approaches to optimize patient outcomes. Summary Management of CMN involves tailored surveillance and intervention strategies, with an emphasis on early identification of high-risk features for MM and neurocutaneous melanosis (NCM). Pediatricians play a crucial role in advocating for sun protection practices and facilitating timely referrals, thereby contributing to the overall well being of pediatric patients with nevi.

show abstract

Clinical and dermoscopic spectrum of age-dependent spitzoid lesions - when to react?

Masirevic-Mudric,

Popadic,

Lalosevic

2024

Srp Arh Celok Lek

View full text Add to dashboard Cite

Introduction. Spitzoid lesions represent a spectrum of melanocytic lesions comprising benign Spitz nevi, intermediate lesions known as atypical Spitz tumors, and Spitzoid melanoma. They tend to be more common in children and young adults, but all age groups can be affected. Due to complexity of their clinical, dermoscopic and histological differentiation, they are extremely difficult-to-manage, especially in pediatric population. Outlines of cases. In this report, we present a series of six cases with spitzoid lesions in different age groups with different outcomes. Conclusion. With the following case series, we report clinical and dermoscopic features of biologically various spitzoid lesions, appearing in different age groups. We believe that this article will increase knowledge of both physicians and dermatologists about when and how to react when dealing with a patient with spitzoid lesion.

show abstract

Spitz Melanocytic Tumors: A Fascinating 75-Year Journey

Cited by 3 publications

References 85 publications

Gene Expression Profile of Benign, Intermediate, and Malignant Spitz and Spitzoid Melanocytic Lesions

Gene Expression Profile of Benign, Intermediate, and Malignant Spitz and Spitzoid Melanocytic Lesions

Nevi – when to refer

Clinical and dermoscopic spectrum of age-dependent spitzoid lesions - when to react?

Contact Info

Product

Resources

About