Spirulina supplementation improves lipid metabolism and autophagic activities in the liver and muscle of Hu lambs fed a high-energy diet

Liang, Yaxu; Huang, Xinai; Zhang, Zhen; Deng, Kaiping; An, Shi; Gao, Xiaoxiao; Wang, Zhen; Liu, Zhinan; Wang, Feng; Liu, Dong; Fan, Yixuan

doi:10.1080/1745039x.2020.1820806

Cited by 6 publications

(3 citation statements)

References 54 publications

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“…We and others have reported that AMPK signaling, besides being essential to maintain cardiac energy metabolism under ischemic stress, induces autophagy protecting against the progression of post-STEMI adverse cardiac remodeling ( Kanamori et al, 2011 ; Vilahur et al, 2016 ; Mendieta et al, 2019b ). A recent study has demonstrated the ability of spirulina to induce mRNA expression levels of autophagy-associated genes (i.e., AMPK and ULK1) in the liver of growing lambs, supporting our findings in the heart tissue ( Liang et al, 2020 ). We also identify lower levels of the inflammatory marker MCP-1 in the entire myocardium of spirulina supplemented pigs.…”

Section: Discussionsupporting

confidence: 91%

Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI

et al. 2022

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Background and Aims: Myocardial infarction (MI) is the clinical manifestation of atherosclerotic coronary artery disease. Spirulina is an algae known to ameliorate cardiometabolic disorders and with proven anti-inflammatory and anti-oxidant effects. We investigated, in a highly translatable animal model, whether oral supplementation with spirulina protects against the deleterious effects triggered by ST-elevation MI (STEMI).Methods: Pigs were fed a regular diet supplemented with spirulina (1 g/animal/bid) or placebo-control for 10 days. Thereafter, animals were subjected to 1.5 h percutaneous balloon-induced coronary occlusion (STEMI) followed by 2.5 h reperfusion and then sacrificed. We assessed infarct size and cardiac function. Blood samples and infarcted and remote myocardial tissue were obtained.Results: Spirulina supplementation reduced infarct size by 64%, increased myocardial salvage by 18%, and improved cardiac function by 30% vs. controls (p < 0.05). These benefits were associated with attenuation in DNA-oxidative damage and apoptotic markers and increased iNOS in the infarcted myocardium, higher AMPK activation in the remote myocardium, and lower myocardial MCP-1 expression. Systemically, spirulina attenuated Cox-2 expression in STEMI-activated peripheral blood mononuclear cells and enhanced TNF-α release acutely post-STEMI. Additionally, spirulina decreased weight gain progression over time (p < 0.05) without changes in lipids, glucose, liver or kidney parameters.Conclusion: A 10-day supplementation with spirulina exerts cardioprotection in a preclinical setting of STEMI by limiting cardiac damage and improving ventricular contractility through anti-oxidative, anti-inflammatory, and anti-apoptotic mechanisms.

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Section: Discussionsupporting

confidence: 91%

Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI

et al. 2022

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“…According to our knowledge, there is no data on spirulina’s effect on autophagy in skin models. However, S. platensis was documented to protect the liver by enhancing the autophagy process against high-energy diets in sheep [ 60 ]. In agreement with our data, rapamycin regulated the proliferation and emigration of fibroblasts from damaged wounds by intensifying the autophagy process [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Enhanced Wound Healing Potential of Spirulina platensis Nanophytosomes: Metabolomic Profiling, Molecular Networking, and Modulation of HMGB-1 in an Excisional Wound Rat Model

et al. 2023

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Excisional wounds are considered one of the most common physical injuries. This study aims to test the effect of a nanophytosomal formulation loaded with a dried hydroalcoholic extract of S. platensis on promoting excisional wound healing. The Spirulina platensis nanophytosomal formulation (SPNP) containing 100 mg PC and 50 mg CH exhibited optimum physicochemical characteristics regarding particle size (598.40 ± 9.68 nm), zeta potential (−19.8 ± 0.49 mV), entrapment efficiency (62.76 ± 1.75%), and Q6h (74.00 ± 1.90%). It was selected to prepare an HPMC gel (SPNP-gel). Through metabolomic profiling of the algal extract, thirteen compounds were identified. Molecular docking of the identified compounds on the active site of the HMGB-1 protein revealed that 12,13-DiHome had the highest docking score of −7.130 kcal/mol. SPNP-gel showed higher wound closure potential and enhanced histopathological alterations as compared to standard (MEBO® ointment) and S. platensis gel in wounded Sprague-Dawley rats. Collectively, NPS promoted the wound healing process by enhancing the autophagy process (LC3B/Beclin-1) and the NRF-2/HO-1antioxidant pathway and halting the inflammatory (TNF-, NF-κB, TlR-4 and VEGF), apoptotic processes (AIF, Caspase-3), and the downregulation of HGMB-1 protein expression. The present study’s findings suggest that the topical application of SPNP-gel possesses a potential therapeutic effect in excisional wound healing, chiefly by downregulating HGMB-1 protein expression.

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“…SP has abundant contents of the macro- and micronutrients, and therefore, it is used to produce safe nutritional and medicinal compounds [ 3 , 4 ]. It could be simply harvested and commercially processed into appropriate forms to be used as human and animal nutrition [ 5 , 6 , 7 , 8 , 9 ]. SP comprises high levels of protein (50–70%), carbohydrates (15–20%), lipids (5–7%), minerals (6–9%), and vitamins (1–4%) [ 1 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Blue-Green Microalgae Inclusion as a Replacement to Soybean Meal on Laying Hens’ Performance, Egg Quality, Plasma Metabolites, and Hematology

Abbas

Alaqil

Mehaisen

et al. 2022

Animals

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Spirulina platensisis (SP) is a blue-green microalgae with a high value for animal and poultry nutrition. The study employed 250 40-week-old, HY-Line W-36 commercial laying hens. The layers received one of five experimental diet substitutes in five groups for 10 consecutive weeks (five replicates of 10 hens each group); a soybean-corn basal diet formulation without SP (Control group) or the soybean partially substituted with 3% SP, 6% SP, 9% SP, and 12% SP (for the remaining four groups). The results showed that dietary SP treatment significantly (p < 0.05) improved the productive performance, egg quality, blood metabolites, and hematological parameters of laying hens. In addition, there were linear and quadratic effects for increasing the levels of SP inclusion into the layer diets; however, the highest values of most parameters were observed when using 9% SP (90 g/kg of the layer diets). Furthermore, the results showed that 4.7% of the soybean meal ingredient in the layer diet could be replaced by 1% of SP. In conclusion, the partial replacement of soybean meal by SP into layer diets could be used as a promising nutritional approach to optimize the performance of laying hens.

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Spirulina supplementation improves lipid metabolism and autophagic activities in the liver and muscle of Hu lambs fed a high-energy diet

Cited by 6 publications

References 54 publications

Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI

Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI

Enhanced Wound Healing Potential of Spirulina platensis Nanophytosomes: Metabolomic Profiling, Molecular Networking, and Modulation of HMGB-1 in an Excisional Wound Rat Model

Effect of Dietary Blue-Green Microalgae Inclusion as a Replacement to Soybean Meal on Laying Hens’ Performance, Egg Quality, Plasma Metabolites, and Hematology

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