Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat

Abstract

The aim of the present work was to assess the capacity of Spirulina maxima to prevent fatty liver development induced in rats by an intraperitoneal single dose (1ml/kg) of carbon tetrachloride. Liver and serum lipids were quantified two or four days after treatment with this agent. Liver lipid concentration did not differ in rats fed on a purified diet with or without Spirulina. However, after carbon tetrachloride treatment, liver triacylglycerols were significantly lower in rats fed on a diet with Spirulina 5% than in rats without Spirulina in their diet (P < 0.05). Furthermore, the increased liver cholesterol values, induced by carbon tetrachloride treatment, were not observed in rats that received Spirulina. These results support the potential hepatoprotective role of Spirulina.

Effect of Stocking Density and Spirulina Platensis Algae Supplementation as a Feed Additive on Performance and Physiological Status of Broiler Chicks

“…In accordance with the present results, Torres-Duran et al, (1998) and Fong et al, (2000) reported significant reduction of cholesterol and triglyceride concentration for rats or mice fed Spirulina diets. The significant reduction in plasma cholesterol of broiler chickens fed dietary Spirulina could be attributed to reducing the absorption and/or synthesis of cholesterol in the gastro-intestinal tract by Spirulina supplementation that increase Lactobacillus population (Tsuchihashi et al, 1987 andMariey, et al, 2012).…”

Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation

“…Previous reports indicate that total cholesterol and triglycerides (TG) increase in CCl 4 -induced fatty liver (Seakins and Robinson, 1963;Torres-Durán et al, 1998). It is well known that CCl 4 administration induces an increased synthesis of fatty acids as well as decreased release of hepatic lipoproteins (Maling et al, 1962).…”

Spirulina in Health Care Management

“…In a study measuring the effect of blue green algae on glucose levels in diabetic rats & mice, the water soluble fraction is found to be effective in lowering the serum glucose level at fasting as well as on glucose loading [74,65]. S. maxima exhibited hypolipidemic effects, especially on triacylglycerols (TAG) and the LDL-Cholesterol [78] and prevented dyslipidemia induced by carbon tetrachloride [77]. The elevation of total cholesterol, LDL and VLDL cholesterol and phospholipids in the serum was reduced significantly when the experimental high cholesterol diet was supplemented with 16% Spirulina [39].…”