Spirulina compounds show hypoglycemic activity and intestinal flora regulation in type 2 diabetes mellitus mice

He, Xiaoyu; Wang, Chang'e; Zhu, Yuxian; Jiang, Xiaoqin; Qiu, Yuyang; Yin, Fei; Xiong, Wenyu; Liu, Bin; Huang, Ying

doi:10.1016/j.algal.2022.102791

Cited by 13 publications

(6 citation statements)

References 49 publications

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“…in T2DM mice. Of which, Erysipelatoclostridium and Weissella are important SCFAs-producing microorganisms, and the relative abundance of Weissella in this study was significantly positively associated with n -valeric acid, n -butyric acid, isovaleric acid, isobutyric acid whereas significantly negatively related to FFA level, which is consistent with many previous studies ( 55 , 56 ). In addition, the relative abundance of Alloprevotella in this study was significantly positively associated with HOMA-ISI and negatively related to levels of FBG, GSP, TBA, TG, TC, and HOMA-IRI.…”

Section: Resultssupporting

confidence: 93%

Sanghuangporus vaninii fruit body polysaccharide alleviates hyperglycemia and hyperlipidemia via modulating intestinal microflora in type 2 diabetic mice

Huang

Chen

et al. 2022

Front. Nutr.

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The disease of type 2 diabetes mellitus (T2DM) is principally induced by insufficient insulin secretion and insulin resistance. In the current study, Sanghuangporus vaninii fruit body polysaccharide (SVP) was prepared and structurally characterized. It was shown that the yield of SVP was 1.91%, and SVP mainly contains small molecular weight polysaccharides. Afterward, the hypoglycemic and hypolipidemic effects and the potential mechanism of SVP in T2DM mice were investigated. The results exhibited oral SVP could reverse the body weight loss, high levels of blood glucose, insulin resistance, hyperlipidemia, and inflammation in T2DM mice. Oral SVP increased fecal short-chain fatty acids (SCFAs) concentrations of T2DM mice. Additionally, 16S rRNA sequencing analysis illustrated that SVP can modulate the structure and function of intestinal microflora in T2DM mice, indicating as decreasing the levels of Firmicutes/Bacteroidetes, Flavonifractor, Odoribacter, and increasing the levels of Weissella, Alloprevotella, and Dubosiella. Additionally, the levels of predicted metabolic functions of Citrate cycle, GABAergic synapse, Insulin signaling pathway were increased, and those of Purine metabolism, Taurine and hypotaurine metabolism, and Starch and sucrose metabolism were decreased in intestinal microflora after SVP treatment. These findings demonstrate that SVP could potentially play hypoglycemic and hypolipidemic effects by regulating gut microflora and be a promising nutraceutical for ameliorating T2DM.

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Section: Resultssupporting

confidence: 93%

Sanghuangporus vaninii fruit body polysaccharide alleviates hyperglycemia and hyperlipidemia via modulating intestinal microflora in type 2 diabetic mice

Huang

Chen

et al. 2022

Front. Nutr.

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“…The metabolites of P in the intestinal tract, GF and PFGF, show a favorable antioxidant activity, which can reduce the alcohol-induced intestinal inflammation [ 43 ]. Both the probiotics and Grifola frondosa have a positive intestinal microbiota regulation ability [ 23 , 44 , 45 ]. They have the ability to attenuate the intestinal inflammation caused by the alcohol-induced flora disorder.…”

Section: Resultsmentioning

confidence: 99%

“…The histopathology of the cecal tissue can reflect the states of the intestinal barrier and inflammation in the intestine. In our previous study, the compounds added with GF improved the jejunum tissue and reduced the level of IL-6 in type 2 diabetes mice, which indicates that GF can alleviate intestinal inflammation [ 45 ]. The results of the cecal tissue sections showed that the P, GF, and PFGF treatments had protective effects on the intestinal barrier.…”

Section: Resultsmentioning

confidence: 99%

Probiotics-Fermented Grifola frondosa Total Active Components: Better Antioxidation and Microflora Regulation for Alleviating Alcoholic Liver Damage in Mice

He¹,

Zhu

Jiang

et al. 2023

IJMS

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Alcoholic liver damage is caused by long-term drinking, and it further develops into alcoholic liver diseases. In this study, we prepared a probiotic fermentation product of Grifola frondosa total active components (PFGF) by fermentation with Lactobacillus acidophilus, Lactobacillus rhamnosus, and Pediococcus acidilactici. After fermentation, the total sugar and protein content in the PFGF significantly decreased, while the lactic acid level and antioxidant activity of the PFGF increased. Afterward, we investigated the alleviating effect of PFGF on alcoholic liver injury in alcohol-fed mice. The results showed that the PFGF intervention reduced the necrosis of the liver cells, attenuated the inflammation of the liver and intestines, restored the liver function, increased the antioxidant factors of the liver, and maintained the cecum tissue barrier. Additionally, the results of the 16S rRNA sequencing analysis indicated that the PFGF intervention increased the relative abundance of beneficial bacteria, such as Lactobacillus, Ruminococcaceae, Parabacteroids, Parasutterella, and Alistipes, to attenuate intestinal inflammation. These results demonstrate that PFGF can potentially alleviate alcoholic liver damage by restoring the intestinal barrier and regulating the intestinal microflora.

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“…Studies have shown that the unique acid and wine aroma of microbial fermented feed induced goats to adopt feed ( Cui et al, 2019 ). It has been reported that Lactobacillus and Weissella can increase the abundance of short-chain fatty acids (SCFAs), and stimulate the development of the gastrointestinal tract by adjusting gastrointestinal flora structure, thereby improve inflammation ( He et al, 2022 ). These findings also support the current results.…”

Section: Discussionmentioning

confidence: 99%

Effects of fermented feed of Pennisetum giganteum on growth performance, oxidative stress, immunity and gastrointestinal microflora of Boer goats under thermal stress

Qiu

Zhao

et al. 2023

Front. Microbiol.

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IntroductionThis study was conducted to evaluate the effects of fermented feed of Pennisetum giganteum (P. giganteum) on growth performance, oxidative stress, immunity and gastrointestinal microflora of Boer goats under thermal stress.MethodsThe study was conducted during 45 days using twenty 2 months Boer goats. The goats were randomly allocated into two groups: NPG (n = 10; normal P. giganteum) and FPG (n = 10; fermented feed of P. giganteum), and the ratio of concentrates to roughage was 3:2. Both groups of animals were kept in sheds and exposed to summer thermal stress from 10:00 h to 18:00 h (temperature and humidity index, THI > 78). At the end of the study, the animals were slaughtered and assessed for various characteristics.ResultsThe findings from the study revealed that FPG-feeding significantly increased (p < 0.05) average daily gain (ADG, 48.18 g) and carcass weight (4.38 kg), while decreased (p < 0.01) average daily feed intake (ADFI, 0.74 kg/d; p < 0.01) and the feed:gain (F/G, 15.36) ratio. The CAT, GSH-Px activities and GSH in serum, liver and spleen, and the levels of IgA, IgG, IgM, IL-2, IL-4 and IL-1β in serum of FPG-fed goats were significantly higher (p < 0.05) than those of NPG-feeding goats. Further, we found that FPG feed is rich in nutrients with Lactobacillus (65.83%) and Weissella (17.80%). Results for gastrointestinal microbiota composition showed that FPG-feeding significantly enhanced the abundance of Lactobacillus and unidentified Clostridiales, and reduced Anaerovibrio and Methanobrevibacter. Meanwhile, Spearman’s correlation analysis showed that these microbiotas were closely related to the improvement of oxidative stress and immune indexes of goats.DiscussionThese results demonstrated that FPG-feeding not only reduces oxidative stress and improves ROS clearance to enhance antioxidant defense system, but also improves gastrointestinal microbiota to enhance immune function by overcoming the adverse effects of heat stress, and further improve growth performance of goats.

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Spirulina compounds show hypoglycemic activity and intestinal flora regulation in type 2 diabetes mellitus mice

Cited by 13 publications

References 49 publications

Sanghuangporus vaninii fruit body polysaccharide alleviates hyperglycemia and hyperlipidemia via modulating intestinal microflora in type 2 diabetic mice

Sanghuangporus vaninii fruit body polysaccharide alleviates hyperglycemia and hyperlipidemia via modulating intestinal microflora in type 2 diabetic mice

Probiotics-Fermented Grifola frondosa Total Active Components: Better Antioxidation and Microflora Regulation for Alleviating Alcoholic Liver Damage in Mice

Effects of fermented feed of Pennisetum giganteum on growth performance, oxidative stress, immunity and gastrointestinal microflora of Boer goats under thermal stress

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