Abstract:The purpose of this study was to evaluate the effects of spironolactone (SPR), started before clinical evidence of heart failure, on cardiac remodeling in spontaneously hypertensive rats (SHR).MethodsThirty six 13 month old SHR were divided into control and SPR (20 mg/kg/day for six months) groups. Systolic blood pressure (BP) was measured by tail‐cuff method. Echocardiogram (ECHO) was performed to evaluate in vivo cardiac structures and left ventricular (LV) function. Myocardial function was analyzed in LV pa… Show more
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