Spironolactone in Diuretic Regimens with Meralluride or Thiazides for Pseudointractable Ascites of Cirrhosis

Gold, Harry; Golfinos, Argyrios J.; Mehta, Dilip; Messeloff, Charles R.; Zahm, William

doi:10.1002/j.1552-4604.1972.tb00033.x

The Journal of Clinical Pharmacology and New Drugs

1972

DOI: 10.1002/j.1552-4604.1972.tb00033.x

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Spironolactone in Diuretic Regimens with Meralluride or Thiazides for Pseudointractable Ascites of Cirrhosis

Harry Gold¹,

Argyrios J. Golfinos²,

Dilip Mehta³

et al.

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“…18 In patients with hepatic cirrhosis or nephrotic syndrome refractory to thiazide diuretics, the addition of spironolactone is frequently effective without severe elec-trolyte disturbances . 16,20,26 The purpose of our study was to compare the individual and combined diuretic effects of metolazone and spironolactone, and to assess the safety of their concurrent administration in patients with chronic hepatic or renal disease.…”

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confidence: 99%

Metolazone and spironolactone in cirrhosis and the nephrotic syndrome

Lang¹,

Westenfelder²,

Nascimento³

et al. 1977

Clin Pharma and Therapeutics

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Eighteen patients with hepatic cirrhosis or nephrotic syndrome and having edema and/or ascites were treated during successive periods with metolazone 5 to 40 mg/day, spironolactone 100 mg/day, and with both diuretics concurrently. Metolazone alone produced a marked diuresis, natriuresis, and weight loss in 8 patients. Spironolactone alone had little effect, but the addition of metolazone renewed diuresis and natriuresis and resulted in additional substantial weight losses in all patients responsive to metolazone alone. Concurrent spironolactone and metolazone also induced moderate diuretic effects in some patients who failed to respond to either drug alone. The drugs were well tolerated; the administration of spironolactone with metolazone prevented decreases in serum potassium, which had occurred during treatment with metolazone alone.

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mentioning

confidence: 99%

Metolazone and spironolactone in cirrhosis and the nephrotic syndrome

Lang¹,

Westenfelder²,

Nascimento³

et al. 1977

Clin Pharma and Therapeutics

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Physiologic Considerations in the Medical Management of Ascites

Frakes¹

1980

Arch Intern Med

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Spironolactone in Diuretic Regimens with Meralluride or Thiazides for Pseudointractable Ascites of Cirrhosis

Cited by 2 publications

References 1 publication

Metolazone and spironolactone in cirrhosis and the nephrotic syndrome

Metolazone and spironolactone in cirrhosis and the nephrotic syndrome

Physiologic Considerations in the Medical Management of Ascites

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