Spirometrically-defined restrictive ventilatory defect: population variability and individual determinants

Soriano, Joan B.; Miravitlles, Marc; García‐Río, Francisco; Muñoz, Luis; Sánchez, Guadalupe; Sobradillo, V.; Durán, Enric; Guerrero, Dolores; Ancochea, Julio

doi:10.4104/pcrj.2012.00027

Cited by 41 publications

(43 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Participants in the US National Health and Nutrition Examination Survey (NHANES) with spirometric restriction were more likely to report functional impairment and fair/poor health than were participants with no lung disease and normal lung function [3,7], and the magnitude of these effects was largely comparable to that seen in subjects with moderate chronic obstructive pulmonary disease (COPD). Similarly, spirometric restriction was found to be associated with worse respiratory-specific health status, as assessed by the St George's Respiratory Questionnaire, in both the COPDGene [5] and Spanish EPI-SCAN [4] studies. However, to what extent the decreased health-related quality of life in spirometric restriction is dependent on the coexistence of respiratory symptoms and comorbidities remains to be determined.…”

Section: Introductionmentioning

confidence: 85%

“…In recent years multiple population-based studies have shown that a significant proportion of the general adult population has a restrictive pattern on spirometry, characterised by reduced levels of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), and normal FEV1/FVC ratio [1][2][3][4]. Although the determinants and biological bases of this restrictive pattern remain largely unknown, subjects with spirometric restriction have been shown to be more likely to have cough and phlegm, shortness of breath with wheezing and dyspnoea [3,[5][6][7], and suffer from and die of a number of comorbidities, including coronary heart disease, hypertension, metabolic syndrome and diabetes [2,[8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Health-related quality of life and risk factors associated with spirometric restriction

et al. 2017

View full text Add to dashboard Cite

The restrictive spirometric pattern is associated with a substantial morbidity and mortality burden. We sought to determine to what extent spirometric restriction is associated with impaired quality of life.We used data from two large population-based European cohorts: 6698 European Community Respiratory Health Survey (ECRHS) and 6069 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) adult participants. The restrictive pattern was defined as forced expiratory volume in 1 s (FEV)/forced vital capacity (FVC) ≥lower limit of normal (LLN) and FVC

show abstract

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Health-related quality of life and risk factors associated with spirometric restriction

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In the study by Mannino et al comprising people age 40 years and above from 14 sites across different continents who took part in the Burden of Obstructive Lung Disease (BOLD) study, the prevalence of restrictive pattern defined by a ratio FEV1/FVC ≥70% and a FVC<80% varied from 6.1% in Sydney (Australia) to 29.3% in Cape Town (South Africa) and 45.9% in Manilla (Philippines) [21]. Soriano et al also found a point prevalence of 12.7% in subjects aged 40 years and above in Spain [22]. In the ≥40 years of age particpants in our study, the prevalence of restrictive pattern was 24.2% (LLN-based) and 20.1% (fixed cut-off based), which is closer to the South African figures in BOLD [21].…”

Section: Discussionmentioning

confidence: 99%

Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study

Pefura-Yone¹,

Balkissou²,

Kengne³

2016

TORMJ

View full text Add to dashboard Cite

BackgroundRestrictive spirometric pattern is a risk factor for all-cause and cause-specific mortality.ObjectiveWe assessed the prevalence of restrictive pattern and investigated its determinants in a major sub-Saharan Africa city.MethodsParticipants were adults (≥ 19 years) who took part in a population-based survey in Yaounde (Cameroon) between December 2013 and April 2014. Restrictive pattern was based on a FVC below the lower limit of the normal (LLN) and a ratio forced expiratory volume in one second (FEV1)/FVC ≥ LLN (LLN-based restrictive pattern) or a FVC <80% and FEV1/FVC ≥ LLN (fixed cut-off based restrictive pattern). Determinants were investigated by logistic regressions.ResultsIn all, 1003 participants [514 (51.2%) women] with a mean age of 33.7 years were included. The prevalence of restrictive pattern was 18.8% (95%CI: 16.6-21.2) based on LLN and 15.0% (13.0-17.2) based on fixed cut-off. LLN-based restrictive pattern was mild in 148 (78.3%) subjects, moderate in 35 (18.5%) and severe in 6 (3.2%). Determinants of LLN-based restrictive pattern were age ≥ 60 years [adjusted odds ratio 2.90 (95%CI 1.46-5.77), p=0.002), history of pulmonary tuberculosis [3.81(1.42-10.20), p=0.008], prevalent heart diseases [3.81 (1.20-12.12), p=0.024] and underweight [5.15(1.30-20.39), p=0.020]. Determinants were largely similar with slightly different effect sizes for fixed cut-off based restrictive pattern.ConclusionRestrictive pattern was very frequent in this city.Clinical implicationsThese results enhance the needs to increase the efforts to prevent and control tuberculosis, cardiovascular diseases and underweight in this setting.

show abstract

“…Further complicating the definition of emphysema is the reduction in FVC that can result from several disorders including obesity. 10,11 This dilemma makes mild COPD difficult to assess in these individuals with present definitions.…”

Section: Definition Of Early Copdmentioning

confidence: 99%

Early chronic obstructive pulmonary disease: definition, assessment, and prevention

2015

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD, however, is a heterogeneous collection of diseases with differing causes, pathogenic mechanisms, and physiological effects. Therefore a comprehensive approach to COPD prevention will need to address the complexity of COPD. Advances in the understanding of the natural history of COPD and the development of strategies to assess COPD in its early stages make prevention a reasonable, if ambitious, goal.

show abstract

Spirometrically-defined restrictive ventilatory defect: population variability and individual determinants

Abstract: Background: A spirometrically-defined restrictive ventilatory defect is a common finding when performing spirometry.

Cited by 41 publications

References 29 publications

Health-related quality of life and risk factors associated with spirometric restriction

Health-related quality of life and risk factors associated with spirometric restriction

Determinants of Restrictive Spirometric Pattern in a Sub-Saharan Urban Setting: A Cross-sectional Population-based Study

Early chronic obstructive pulmonary disease: definition, assessment, and prevention

Contact Info

Product

Resources

About