Spirometric abnormalities among welders

Rastogi, Shivani; Husain, Tanveer; Mathur, Neeraj; Srivastava, S. K.

doi:10.1016/s0013-9351(05)80105-7

Cited by 25 publications

(19 citation statements)

References 14 publications

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“…: some subjects did not have complete questionnaire data; } : cases include subjects that developed at least one W-R RS suggestive of occupational asthma (OA) at least once during the study; z : cases include subjects that developed at least one W-R RS suggestive of OA at first follow-up that persisted until the second follow-up or the development of at least one W-R RS as of the second follow-up. [2][3][4][5][6][7][8][9], has been previously noted in epidemiological studies, with greater effects observed in smokers [6,13,27,28], confirming the role of smoking as the main risk factor leading to the decline in lung function. The absence of an influence of smoking in this study could be partly explained by the current study subjects being young adults who consequently would not have been significantly affected by respiratory conditions due to cigarette smoking.…”

Section: Discussionsupporting

confidence: 67%

“…These studies have not consistently demonstrated an impairment of pulmonary function in occupationally exposed welders [1]. However, there is now good evidence of a higher prevalence of ventilatory impairment in welders shown by significantly lower pulmonary function indices than in comparable controls [2][3][4][5][6][7][8][9]. The confounding effect of smoking has been demonstrated [5,6,10].…”

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confidence: 99%

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Incidence of probable occupational asthma and changes in airway calibre and responsiveness in apprentice welders

El‐Zein

Malo²,

Infante‐Rivard³

et al. 2003

Eur Respir J

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The majority of cross-sectional studies have shown a higher prevalence of ventilatory impairment in welders while only few longitudinal studies were able to detect chronic effects on spirometry or bronchial responsiveness.The aim of the study was to determine the incidence of probable occupational asthma (OA), bronchial obstruction and hyperresponsiveness among 286 students entering an apprenticeship programme in the welding profession.This epidemiological prospective cohort study consisted of a baseline assessment survey and two follow-up assessments. A respiratory symptom questionnaire was administered at each visit. Spirometry and methacholine bronchial challenge test results, conducted once prior to onset of exposure and later after an average of 15 months of apprenticeship, were available for 194 subjects.The incidence of probable OA was y3% (6 of 194). The incidence of bronchial hyperresponsiveness, defined as a o3.2-fold decrease in the provocative concentration causing a 20% fall in the forced expiratory volume in one second from baseline to the end of the study was 11.9%. A statistically significant difference was found between the baseline and end of study for the lung function values. In particular, the forced expiratory volume per cent predicted had significantly dropped by 8.4% on average.The significance of these early pulmonary function changes in relation to possible chronic effects of exposure to welding fumes and gases remains to be explored. Since the 1980s, epidemiological studies investigated the effects of exposure to welding fumes and gases on lung function and clinical manifestations in welders. The assessment of the effect on pulmonary function is limited, in that most studies have been cross-sectional in design, conducted in groups of welders and nonwelder referents. These studies have not consistently demonstrated an impairment of pulmonary function in occupationally exposed welders [1]. However, there is now good evidence of a higher prevalence of ventilatory impairment in welders shown by significantly lower pulmonary function indices than in comparable controls [2-9]. The confounding effect of smoking has been demonstrated [5,6,10]. Studies of short-term respiratory function have shown a greater reduction in lung function indices among welders than among nonwelders [3,11].There have been relatively few published longitudinal studies. A 2-yr follow-up study showed no significant overall difference in the annual change in pulmonary function variables between welders and nonwelders; however, smoking welders and those welding without local exhaust ventilation or respiratory protection had significantly increased risks for accelerated decline in the forced expiratory volume in one second (FEV1) [12]. This confirmed earlier findings by CHINN et al. [13] in a group of shipyard welders. A 3-yr prospective cohort study on airway reactivity in a group of shipyard workers, including 51 arc welders and 54 nonwelders, showed that welding was associated with a transient across-work-shif...

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Section: Discussionsupporting

confidence: 67%

mentioning

confidence: 99%

Incidence of probable occupational asthma and changes in airway calibre and responsiveness in apprentice welders

El‐Zein

Malo²,

Infante‐Rivard³

et al. 2003

Eur Respir J

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“…As the main parameter of airway obstruction, FEV 1 is used to determine the degree of lung function impairment (47). Our results showed an (48). Anaemia observed in lead-exposed individuals is of the hypochromic and normocytic (also microcytic) type, and is accompanied by reticulocytosis with basophilic stippling.…”

Section: Discussionsupporting

confidence: 55%

Adverse Effects in Workers Exposed to Inorganic Lead

Stoleski¹,

Karadžinska-Bislimovska²,

Стикова³

et al. 2008

Archives of Industrial Hygiene and Toxicology

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This paper describes a retrospective cohort study comparing 60 workers occupationally exposed to inorganic lead and 60 matched controls. All subjects were assessed using data obtained from a specially designed Questionnaire for lead exposure and toxic effects assessment, physical examination, spirometry, ECG, and laboratory tests including blood lead level (BLL) and biomarkers of lead toxic effects. Muscle pain, droopiness, and work-related nasal symptoms were significantly more frequent in lead workers. The prevalence of lung symptoms was higher in lead workers than in controls, but not significantly (20 % vs. 6.6 %, respectively). Mean values of BLL and δ-aminolevulinic acid (ALA) were significantly higher in lead workers. The activity of δ-aminolevulinic acid dehydratase (ALAD) in lead workers was significantly lower than in controls. Abnormal of BLL, ALAD, and ALA were more frequent in lead workers, with statistical difference for BLL and ALAD. Inverse correlation was found between BLL and ALAD, and positive correlation between BLL and age, years of employment, and years of exposure. Inverse correlation was found between ALAD and age, years of employment, years of exposure, blood pressure, alcohol consumption, and years of alcohol consumption. Changes in spirometry correlated inversely with BLL. A positive correlation was found between BLL and erythrocyte count and haemoglobin concentration, whereas it was inverse for ALAD and haemoglobin concentration. A significant difference was found for BLL and ALAD, with a very high odds ratio (14.64 and 7.23, respectively) and high relative risk (4.18 and 3.08, respectively). Our data have confirmed the association between occupational lead exposure and deviation in specific biological markers of lead effect and between the role of occupational exposure in the development of adverse effects.

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“…(Mur et al 1987;Rastogi et al 1991;Schneider et al 1987;Zober und Weltle 1985). Besonders gefährdet waren Schweißer, die unter beengten räumlichen Verhält-nissen arbeiteten.…”

Section: Erfahrungen Beim Menschenunclassified

Eisenoxide (einatembare Fraktion) [MAK Value Documentation in German language, 2011]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 51. Lieferung, Ausgabe 2011 Der Artikel enthält folgende Kapitel: Allgemeine Charakterisierung Vorkommen Lagerstätten und Hauptförderländer Herstellung und Verwendung Rohstoffe Herstellungs‐ und Verarbeitungsprozess Herstellung synthetischer Eisenoxide (Pigmente) Verwendungsgebiete ― Eisenoxide Messverfahren Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Spirometric abnormalities among welders

Cited by 25 publications

References 14 publications

Incidence of probable occupational asthma and changes in airway calibre and responsiveness in apprentice welders

Incidence of probable occupational asthma and changes in airway calibre and responsiveness in apprentice welders

Adverse Effects in Workers Exposed to Inorganic Lead

Eisenoxide (einatembare Fraktion) [MAK Value Documentation in German language, 2011]

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