Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae)

Castillo, Denis; Arévalo, Jorge; Herrera, F.; Ruiz, Candy; Rojas, Rosario; Rengifo, Elsa; Vaisberg, Abraham; Ugaz, Olga Lock de; Lemesre, Jean-Loup; Gornitzka, H.; Sauvain, Michel

doi:10.1016/j.jep.2007.03.025

Cited by 55 publications

(36 citation statements)

References 19 publications

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“…This activity was attributed to plumericine and isoplumericine [17] which are compounds with nonpolar and hydrophobic character, crossing easily plasma membrane of the parasite [18]. The inactivity of H. articulatus extract and its fractions in promastigote may be related to the major iridoid plumeride .…”

Section: Discussionmentioning

confidence: 99%

Anti-promastigote Activity of the Amazon Plants

Silva-Silva¹,

Monteiro²,

Brígido³

et al. 2017

JPP

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This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was evaluated through the cell viability assessment method (MTT). The ethanol extract, fractions, and isolated substance from Himatanthus articulatus and Parahancornia fasciculata were inactive in promastigote of L. amazonensis, as the ethanol extract of Physalis angulata. The hexane fractions from different parts of Montrichardia linifera showed anti-promastigote activity probably due to the presence of steroids and terpenes. All species in studies were inactive, except of M. linifera. The few polar constituents can be responsible for the activity. Therefore, the isolation and purification of the active on L. amazonensis promastigotes are urgently required.

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Section: Discussionmentioning

confidence: 99%

Anti-promastigote Activity of the Amazon Plants

Silva-Silva¹,

Monteiro²,

Brígido³

et al. 2017

JPP

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“…Os alcaloides indólicos dos representantes do gênero apresentam diversas atividades farmacológicas, entre elas antimicrobiana (Silva et al, 1998;Neto et al, 2002;Morel et al, 2006), antitumoral (Wood et al, 2001), antiprotozoária (Deharo et al, 2001;Mesquita et al, 2005;Castillo et al, 2007) e anti-inflamatória (Miranda et al, 2000). Himatanthus lancifolius (Müll.…”

Section: Introductionunclassified

Himatanthus lancifolius (Müll. Arg.) Woodson, Apocynaceae: estudo farmacobotânico de uma planta medicinal da Farmacopeia brasileira 1ª edição

Baratto¹,

Hohlemwerger²,

Guédès³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:Himatanthus lancifolius (Müll. Arg.) Woodson é um arbusto nativo do Brasil, latescente, popularmente conhecido como agoniada e utilizado principalmente para distúrbios menstruais. O presente trabalho teve como objetivo caracterizar morfoanatomicamente a folha, o caule e a casca caulinar dessa planta medicinal, a fim de contribuir para o controle de qualidade e a autenticidade dessa espécie. O material vegetal foi fixado e submetido às microtécnicas usuais. A folha é simples, glabra e obovado-lanceolada. A epiderme é uniestratificada, revestida por cutícula estriada e possui estômatos anisocíticos na face abaxial. O mesofilo é dorsiventral. A nervura central é biconvexa e o pecíolo é circular, ambos apresentando feixes vasculares bicolaterais. Laticíferos, amiloplastos e idioblastos fenólicos estão presentes no parênquima fundamental da nervura central e do pecíolo. O sistema vascular do caule é tipicamente bicolateral. Laticíferos e idioblastos fenólicos ocorrem no córtex, no floema e na medula. Esses caracteres morfoanatômicos, em conjunto, podem ser utilizados como parâmetros para o controle de qualidade dessa espécie.Unitermos: Apocynaceae, floema interno, Himatanthus lancifolius, laticíferos, morfoanatomia.ABSTRACT: "Himatanthus lancifolius (Müll. Arg.) Woodson, Apocynaceae: morphoanatomical study of a medicinal plant described in the Brazilian Pharmacopoeia 1st edition". Himatanthus lancifolius (Müll. Arg.) Woodson is a Brazilian native shrub, laticiferous, popularly known as "agoniada". It is mainly used for uterine disorders. The present work aimed to study the leaf, stem and stem bark morpho-anatomy of this medicinal plant, in order to contribute to its quality control and identification. The plant material was fixed and submitted to standard microtechniques. The leaf is simple, glabrous and obovate-lanceolate. The epidermis is uniseriate, coated with striated cuticle and it has anysocitic stomata on the abaxial surface. The mesophyll is dorsiventral. The midrib is biconvex and the petiole is circular, both present bicollateral vascular bundles. Laticiferous ducts, amyloplasts and phenolic idioblasts are found in ground parenchyma of the midrib and petiole. The vascular system of the stem is tipically bicollateral. Laticiferous ducts and phenolic idioblasts are present in the cortex, phloem and pith. These morpho-anatomical characters, all together, can be used as quality control parameters of this species.

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“…Murine macrophages were harvested from peritoneal cavities of 6-8 week-old female BALB/c mice in ice-cold M199 medium supplemented with 10 % FBS 20 .…”

Section: Synthesis Of Quinoxaline and Quinoxaline 14-di-n-oxide Derimentioning

confidence: 99%

“…Differentiated murine peritoneal macrophages were treated with drugs and the trypan blue dye exclusion method was used 20 . Dilutions in complete medium were then added to achieve a final volume of 100 µl.…”

Section: Toxicity Assaymentioning

confidence: 99%

Trypanocidal properties, structure–activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives

Estevez

Quiliano

Burguete

et al. 2011

Experimental Parasitology

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Two series of pyrazol and propenone quinoxaline derivatives were tested for parasiticidal activity (against amastigotes of Leishmania peruviana and trypomastigotes of Trypanosoma cruzi) and for toxicity against proliferative and non-proliferative cells. The pyrazol series was almost inactive against1,4-dioxide inhibited 50% of Leishmania growth at 8.9 µM with no impact against proliferative kidney cells and low toxicity against Thp-1 and murine macrophages. The compounds of the propenone series were moderately active against T. cruzi. Among them, 2 compounds were particularly interesting: (2E)-1-(7-Fluoro-3-methyl-quinoxalin-2-yl)-3-(3,4,5-trimethoxy-phenyl)-propenone, that showed a selective activity against proliferative cells (cancer and parasites), being inactive against normal murine peritoneal macrophages and (2E)-3-(3,4,5-Trimethoxy-phenyl)-1-(3,6,7-trimethyl-quinoxalin-2-yl)-propenone that was only active against Leishmania and inactive against the other tested cells.Furthermore in silico studies were performed for ADME properties and docking studies, both series of compounds respected the Lipinski's rules and show linear correlation between tripanosomaticidal activities and LogP. Docking studies revealed that compounds of the second series could interact with the poly (ADP-ribose) polymerase protein of Trypanosoma cruzi.3

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Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae)

Cited by 55 publications

References 19 publications

Anti-promastigote Activity of the Amazon Plants

Anti-promastigote Activity of the Amazon Plants

Himatanthus lancifolius (Müll. Arg.) Woodson, Apocynaceae: estudo farmacobotânico de uma planta medicinal da Farmacopeia brasileira 1ª edição

Trypanocidal properties, structure–activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives

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