Spiroindole-containing compounds bearing phosphonate group of potential Mpro-SARS-CoV-2 inhibitory properties

Bekheit, Mohamed S.; Panda, Siva S.; Kariuki, Benson M.; Mahmoud, Sarah H.; Mostafa, Ahmed; Girgis, Adel S.

doi:10.1016/j.ejmech.2023.115563

Cited by 4 publications

(2 citation statements)

References 58 publications

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“…Synthesis of spiroindoles 20 through azomethine ylide cycloaddition [149]. Anti-SARS-CoV-2 spiroindole-containing compounds bearing a phosphonate group 21 (J1-J3) were recently reported with potential M pro inhibitory properties, synthesized through azomethine (generated from the reaction of isatin and sarcosine) reaction with the appropriate 3,5-bis((E)-ylidene)-1-phosphonate-4-piperidone [150] (Scheme 10).…”

Section: Spiroindolesmentioning

confidence: 99%

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Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

Girgis,

Panda,

Kariuki

et al. 2023

Molecules

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The COVID-19 pandemic has posed a significant threat to society in recent times, endangering human health, life, and economic well-being. The disease quickly spreads due to the highly infectious SARS-CoV-2 virus, which has undergone numerous mutations. Despite intense research efforts by the scientific community since its emergence in 2019, no effective therapeutics have been discovered yet. While some repurposed drugs have been used to control the global outbreak and save lives, none have proven universally effective, particularly for severely infected patients. Although the spread of the disease is generally under control, anti-SARS-CoV-2 agents are still needed to combat current and future infections. This study reviews some of the most promising repurposed drugs containing indolyl heterocycle, which is an essential scaffold of many alkaloids with diverse bio-properties in various biological fields. The study also discusses natural and synthetic indole-containing compounds with anti-SARS-CoV-2 properties and computer-aided drug design (in silico studies) for optimizing anti-SARS-CoV-2 hits/leads.

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Section: Spiroindolesmentioning

confidence: 99%

“…Scheme 10. Synthesis of spiroindole-containing compounds 21 (J1-J3) bearing a phosphonate group[150].…”

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confidence: 99%

Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

Girgis,

Panda,

Kariuki

et al. 2023

Molecules

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Synthesis of phosphonate-containing compounds

Hajinasiri

2023

Tetrahedron

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Indole-based compounds as potential drug candidates for SARS-CoV-2

Girgis,

Panda,

Kariuki

et al. 2023

Preprint

View full text Add to dashboard Cite

The COVID-19 pandemic has posed a significant threat to society in recent times, endangering human health, life, and economic well-being. The disease spreads quickly due to the highly infectious SARS-CoV-2 virus, which has undergone numerous mutations. Despite intense research efforts by the scientific community since its emergence in 2019, no effective therapeutics have been discovered yet. While some repurposed drugs have been used to control the global outbreak and save lives, none have proven universally effective, particularly for severely infected patients. Although the spread of the disease is generally under control, anti-SARS-CoV-2 agents are still needed to combat current and future infections. This study reviews some of the most promising repurposed drugs containing indolyl heterocycle, which is an essential scaffold of many alkaloids with diverse bio-properties in various biological fields. The study also discusses natural and synthetic indole-containing compounds with anti-SARS-CoV-2 properties, as well as computer-aided drug design (in-silico studies) for optimizing anti-SARS-CoV-2 hits/leads.

show abstract

Spiroindole-containing compounds bearing phosphonate group of potential Mpro-SARS-CoV-2 inhibitory properties

Cited by 4 publications

References 58 publications

Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

Synthesis of phosphonate-containing compounds

Indole-based compounds as potential drug candidates for SARS-CoV-2

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