Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures

Application and Method of Surface Plasmon Resonance Technology in the Preparation and Characterization of Biomedical Nanoparticle Materials

“…High-throughput SPR combines speed, automation, quantitative analysis, and versatility, making it a powerful tool for accelerating drug discovery, biomarker identification, and optimization of therapeutic candidates in biomedical research and pharmaceutical development. 120 , 121 To meet the research and application needs in the biomedical field, the development of new technologies and devices based on high-throughput SPR technology will receive increased attention.…”

Patumantanes A–D, seco-Polycyclic Polyprenylated Acylphloroglucinols with Diverse Carbon Skeletons from Hypericum patulum

“…Hypericum patulum is a perennial shrub widely distributed in China and often used to treat gonorrhea and hepatitis. , Previously, we have investigated the chemical constituents of H. patulum. − In our continuous pursuit of bioactive metabolites from this plant, four novel PPAPs, patumantanes A–D ( 1 – 4 ) were isolated (Figure ). Patumantane A ( 1 ) possessed an unprecedented 3,7-dioxatetracyclo­[7.7.0.0 1,6 .1 11,15 ]­heptadecane core based on an unusual 1,2- seco -homoadamantane skeleton that was formed by the secession of C-1–C-2 linkage at the acylphloroglucinol core via retro-Claisen reaction, as well as esterification from 19–OH to C-2.…”