Spirochaetae in Syphilis

McWeeney, E. J.

doi:10.1136/bmj.1.2319.1262

Cited by 4 publications

(2 citation statements)

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“…At the phylum level, the abundance of Spirochaetae was significantly reduced in group T compared with group L; while upon aging, there was an increased abundance of Spirochaetae in group L compared with group C. Interestingly, treatment with GLP-2 results in a reduction in Spirochaetae in aging rats; this result is in contrast to the increase in abundance in Spirochaetae caused by aging in non-treated rats. Some members of the genus Spirochaetae including Leptospira , Borrelia and Treponema are pathogenic, causing diseases such as syphilis [ 22 ], leptospirosis, relapsing fever, dilated cardiomyopathy [ 23 ] and gingivitis [ 24 ]. Thus, GLP-2 is capable of reducing age-induced increases in the prevalence of some pathogens in rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of Aging and Glucagon-like Peptide 2 on Intestinal Microbiota in SD Rats

Wu¹,

Ren²,

Li³

et al. 2018

Aging and disease

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Recent research suggests that intestinal microbiota affect the aging process. Glucagon-like peptide 2 (GLP-2), a growth factor found in the intestinal mucosal epithelium, reduces intestinal permeability and affects intestinal microbiota. The relationship between aging, GLP-2, and intestinal microbiota are still not well understood. The current study examined the influence of aging and GLP-2 on the intestinal microbiota of rats. Twelve 3-month old male SD rats were randomly divided into two groups: a young control group (group C) and a young GLP-2 treatment group (group G). Twelve 26-month old male SD rats were randomly divided into two groups: an aged control group (group L) and an aged GLP-2 treatment group (group T). GLP-2 was intraperitoneally injected into rats from group G and group T for 14 days. Plasma GLP-2 concentration was evaluated by ELISA tests. Fresh intestinal stool samples were collected from each group and total fecal bacterial genomic DNA was extracted from the associated rats. The bacterial composition of fecal samples was analyzed by Miseq high-throughput sequencing and comparison with SRA databases. Overall, the diversity of intestinal microbiota significantly decreases with age in SD rats, while GLP-2 has no significant effect on the diversity of intestinal microbiota. Upon aging, there is a reduction in probiotic bacteria and a concomitant increase in pathogenic bacteria in rats. Treatment with GLP-2 results in a significant reduction in the prevalence of pathogenic bacterial genera and an increase in some potential benefit bacteria in aged rats. In addition, treatment with GLP-2 results in an increase in several probiotics and a reduction in the prevalence of pathogenic bacterial genera in young rats.

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Section: Discussionmentioning

confidence: 99%

Effect of Aging and Glucagon-like Peptide 2 on Intestinal Microbiota in SD Rats

Wu¹,

Ren²,

Li³

et al. 2018

Aging and disease

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“…Artifacts and macrobotanical remains were separated from selected soil samples using the flotation method, while other soil samples were stored in a cool location for radiocarbon and/or microbotanical analysis. Pollen and phytolith analysis was performed by R. A. Varney, Chad Yost, and Linda Scott Cummings of the Paleo Research Institute in Golden, Colorado (Varney et al, 2009); macrobotanical remains were analyzed by Lucinda J. McWeeney, of Archaeo/Botanical IDs, Seneca Falls, New York (McWeeney, 2010); and diatoms were identified by Thomas Whitmore, of St. Petersburg, Florida (Whitmore, 2010). Radiocarbon dating was conducted by Beta Analytic, Inc., of Miami, Florida.…”

Section: Methodsmentioning

confidence: 99%

Assessing Intra-Watershed Paleoenvironment and Landform Development: A Case Study from South-Central Pennsylvania

Coppock¹,

Stiteler²,

Vento

2011

North American Archaeologist

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Through the detailed multidisciplinary investigation of a single drainage basin, the Aughwick Creek watershed study has produced new insights into the paleoenvironment of the Appalachian Mountain region of south-central Pennsylvania. This study characterized seven alluvial landforms (T-00 to T-5), produced paleobotanical data extending back to the Plum Point interstadial nearly 30,000 BP, and identified evidence suggesting that a former lake existed within the valley sometime between 22,000 and 15,000 BP. In addition to generating information critical to interpreting local prehistoric sites, this study also produced data needed to identify archaeologically sensitive areas within the region and to estimate the appropriate level of effort that would be required to identify buried sites on a wide variety of landforms. Although the specific results of this study apply only to this watershed and similar regions of the Ridge and Valley's Appalachian Mountain section, the general approach could be utilized in a wide variety of settings, including those with aeolian and colluvial deposition.

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Sammelreferat über Spirochaetenbefunde bei Syphilis

Mulzer

1906

Arch. f. Dermat.

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Ende April 1905 erschien yon Schaudinn und E. Hoffmann ein ,Vorl~ufiger Bericht fiber das Vorkommen yon Spirochaeten in syphili~ischen Krankheitspr0dukten und bei Papillomen~. Die Vcrfasser Ceilten mit, daJ] sie iu den verschiedenen Produkten frischer Syphilis Stets eine dureh ihre Zartheit, sehwache Y{irbbarkeit und korkzieherartige Gestalt der Windungen ausgezeichnete Spirochaete h~tten nachweisen kSnnen. Diese Entdeckung machte das gr51~te Aufsehen and lenkte yon neuem die Aufmerksamkeit der gesamten ~irztlichen Welt auf das Studium der Spirochaeten, die ja schon seit Ianger Zeit bekannt waren, und deren Bedeutung ffir die menschliehe Pathologie seit der Entdeckung der Spirochaete O b er m e y e r i nieht mehr zweifelhaft sein konnte.Fast allseitig siad die Befunde Schaudinns uud Hoffmanns best~tigt worden, und so ist die Literatur fiber diesen Gegenstand in wenigen Monaten ungeheuer angewaehsen. Auf Anregung yon Herrn Pros H o ffm a n n in Berlin und Herrn Prof. Scholtz in K5nigsberg, welch letzterem ich insbesondere fiir seine Unterstiitzung dankbar bin, habe ich es unternommen, die in allen Fachzeitschriften zerstreuten Mitteilungen uud Publikationea zu sammeln, fiber ihre Resultate zu beriehten and eine kurze Ubersicht fiber den jetzigen Stand der Spirochaetenfrage zu geben.') ~) Bis 1. Januar 1906. 25*

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Spirochaetae in Syphilis

Cited by 4 publications

References 0 publications

Effect of Aging and Glucagon-like Peptide 2 on Intestinal Microbiota in SD Rats

Effect of Aging and Glucagon-like Peptide 2 on Intestinal Microbiota in SD Rats

Assessing Intra-Watershed Paleoenvironment and Landform Development: A Case Study from South-Central Pennsylvania

Sammelreferat über Spirochaetenbefunde bei Syphilis

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