Abstract:Spiro compounds play an important role in organic chemistry, not only as key structural units in many natural products and pharmaceuticals but also as useful building blocks in synthetic chemistry. This review deals with the synthesis and application of spiro heterocycles, especially spiro pyrazol-3-ones (SPOs). SPOs represent a common scaffold present in a wide range of biological active compounds, such as antibacterial, analgesic, phosphodiesterase, inotropic, acetyl-CoA carboxylase, PPARa, RaIA, and antitum… Show more
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