Spirally Arrayed Electrode for Spatially Selective and Minimally Displacive Peripheral Nerve Interface

Kim, Ockchul; Choi, Wonsuk; Jung, Woohyun; Jung, Soyoung; Park, Hyung Dal; Jeong, Jin‐Woo; Chu, Jun-Uk; Park, Jong Woong; Kim, Jinseok

doi:10.1109/jmems.2020.2996220

Cited by 4 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 9 shows the printed circuit board (PCB) and implantable stimulation system. The epidural electrode was designed and manufactured using a microelectromechanical systems (MEMS) technique [21,22]. Table III presents the specifications including materials, thickness, and dimensions of the electrode.…”

Section: F System Integration With Biocompatible Packagingmentioning

confidence: 99%

Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study

Kang,

Lee,

Choi

et al. 2023

IEEE Trans. Neural Syst. Rehabil. Eng.

Self Cite

View full text Add to dashboard Cite

Spinal cord stimulation (SCS) is an emerging therapeutic option for patients with neuropathic pain due to spinal cord injury (SCI). Numerous studies on pain relief effects with SCS have been conducted and demonstrated promising resultswhile the mechanisms of analgesic effect during SCS remain unclear. However, an experimental system that enables large-scale long-term animal studies is still an unmet need for those mechanistic studies. This study proposed a fully wireless neurostimulation system that can efficiently support a long-term animal study for neuropathic pain relief. The developed system consists of an implantable stimulator, an animal cage with an external charging coil, and a wireless communication interface. The proposed device has the feature of remotely controlling stimulation parameters via radio-frequency (RF) communication and wirelessly charging via magnetic induction in freely moving rats. Users can program stimulation parameters such as pulse width, intensity, and duration through an interface on a computer. The stimulator was packaged with biocompatible epoxy to ensure long-term durability under in vivo conditions. Animal experiments using SCI rats were conducted to demonstrate the functionality of the device, including long-term usability and therapeutic effects. The developed system can be tailored to individual user needs with commercially available components, thus providing a costeffective solution for large-scale long-term animal studies on neuropathic pain relief.

show abstract

Section: F System Integration With Biocompatible Packagingmentioning

confidence: 99%

Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study

Kang,

Lee,

Choi

et al. 2023

IEEE Trans. Neural Syst. Rehabil. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The neural interface proposed in this study used SPAE (Spiral Probe Array Electrode) [25], a photosensitive polyimide-based neural electrode developed through previous studies; the neural interface system is constructed by connecting PCB integrated with pre-amplifier (RHS2116 Stim/Amplifier Chip, Intan Technologies, Los Angeles, CA, USA) and FPCB (Flexible Printed Circuit Board).…”

Section: Design and Fabrication Of Polymer-based Neural Interface Pac...mentioning

confidence: 99%

“…The stimulation probe was connected to the electric pulse generator to apply stimulation, and the neural electrode applied to the neural interface was implanted into the sciatic nerve of the rabbit for signal acquisition. Implantation of the neural electrode was performed using a surgical method established using rats in previous study [25], and a 12-week-old New Zealand male white rabbit was anesthetized through laparoscopic injection of a Zoletil (Virbac, Carros, France)-Rompun (BAYER, Leverkusen, Germany) with composition ratio of 3:1. After anesthetizing, the neural electrode was inserted into the sciatic nerve, which was exposed through a muscle incision.…”

Section: In Vivo Experiments Setupsmentioning

confidence: 99%

A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation

Park

Choi

et al. 2022

Micromachines

Self Cite

View full text Add to dashboard Cite

This paper proposed and verified the use of polymer-based packaging to implement the chronic implantation of neural interfaces using a combination of a commercial thermal epoxy and a thin parylene film. The packaging’s characteristics and the performance of the vulnerable interface between the thermal epoxy layer and polyimide layer, which is mainly used for neural electrodes and an FPCB, were evaluated through in vitro, in vivo, and acceleration experiments. The performance of neural interfaces—composed of the combination of the thermal epoxy and thin parylene film deposition as encapsulation packaging—was evaluated by using signal acquisition experiments based on artificial stimulation signal transmissions through in vitro and in vivo experiments. It has been found that, when commercial thermal epoxy normally cured at room temperature was cured at higher temperatures of 45 °C and 65 °C, not only is its lifetime increased with about twice the room-temperature-based curing conditions but also an interfacial adhesion is higher with more than twice the room-temperature-based curing conditions. In addition, through in vivo experiments using rats, it was confirmed that bodily fluids did not flow into the interface between the thermal epoxy and FPCB for up to 18 months, and it was verified that the rats maintained healthy conditions without occurring an immune response in the body to the thin parylene film deposition on the packaging’s surface.

show abstract

“…What is popular as a fabrication process is printing technology such as that of the flexible plastic foils attached to the body [30]. Wearable health technology products can be employed to monitor tears, temperature, wound, breath, sweat, and blood pressure [31][32][33][34][35].…”

Section: Wearable Medical Devicesmentioning

confidence: 99%

Magic of 5G Technology and Optimization Methods Applied to Biomedical Devices: A Survey

2022

View full text Add to dashboard Cite

Wireless networks have gained significant attention and importance in healthcare as various medical devices such as mobile devices, sensors, and remote monitoring equipment must be connected to communication networks. In order to provide advanced medical treatments to patients, high-performance technologies such as the emerging fifth generation/sixth generation (5G/6G) are required for transferring data to and from medical devices and in addition to their major components developed with improved optimization methods which are substantially needed and embedded in them. Providing intelligent system design is a challenging task in medical applications, as it affects the whole behaviors of medical devices. A critical review of the medical devices and the various optimization methods employed are presented in this paper, to pave the way for designers to develop an apparatus that is applicable in the healthcare industry under 5G technology and future 6G wireless networks.

show abstract

Spirally Arrayed Electrode for Spatially Selective and Minimally Displacive Peripheral Nerve Interface

Cited by 4 publications

References 23 publications

Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study

Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study

A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation

Magic of 5G Technology and Optimization Methods Applied to Biomedical Devices: A Survey

Contact Info

Product

Resources

About