Spiral peripheral nerve interface; updated fabrication process of the regenerative implant

Barrett, Richard; Benmerah, Samia; Frommhold, Andreas; Tarte, E.J.

doi:10.1109/embc.2013.6609614

Cited by 3 publications

(9 citation statements)

References 12 publications

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“…By using an active ASIC layer in an MNI design every microchannel can be addressed, in this case to a total of seven layers and 49 microchannels, while requiring only a 5-line bus. Due to the use of passive conductors previous MNI designs have been limited in the number of channels for stimulating and recording e.g., [28], [30], [31]. Here, reducing the number of interconnect wires has the additional advantage of reducing surgical complexity and failure risk due to cable damage [51].…”

Section: Discussionmentioning

confidence: 99%

“…This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/ The spiral peripheral nerve interface design, rolled to form 50 microchannels as described in [30]. Part (b) modified from [35].…”

Section: Introductionmentioning

confidence: 99%

“…MNIs have been manufactured with a range of techniques: silicone casting [23], photopatterning polyimides [20], [29], [30], silicones [28], SU-8 photoresist [25], [31], and laser micromachining [32]. Existing MNI designs use passive conductors (metal thin-films, wires, or foils) to form electrodes and interconnects.…”

Section: Introductionmentioning

confidence: 99%

“…Fig. 1(c) shows the interconnect size requirements for a spiral peripheral nerve interface with 10 channels containing electrodes (devices with up to 20 electrode channels have been reported [30]). Tripole end electrodes add further connections, one for common end electrodes, and up to two additional connections per channel.…”

Section: Introductionmentioning

confidence: 99%

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An ASIC for Recording and Stimulation in Stacked Microchannel Neural Interfaces

Lancashire

Jiang

Demosthenous

et al. 2019

IEEE Trans. Biomed. Circuits Syst.

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This paper presents an active microchannel neural interface (MNI) using seven stacked application specific integrated circuits (ASICs). The approach provides a solution to the present problem of interconnect density in three-dimensional (3-D) MNIs. The 4 mm 2 ASIC is implemented in 0.35 µm high-voltage CMOS technology. Each ASIC is the base for seven microchannels each with three electrodes in a pseudo-tripolar arrangement. Multiplexing allows stimulating or recording from any one of 49 channels, across seven ASICs. Connections to the ASICs are made with a fiveline parallel bus. Current controlled biphasic stimulation from 5 to 500 µA has been demonstrated with switching between channels and ASICs. The high-voltage technology gives a compliance of 40 V for stimulation, appropriate for the high impedances within microchannels. High frequency biphasic stimulation, up to 40 kHz is achieved, suitable for reversible high frequency nerve blockades. Recording has been demonstrated with mV level signals; commonmode inputs are differentially distorted and limit the CMRR to 40 dB. The ASIC has been used in vitro in conjunction with an oversize (2 mm diameter) microchannel in phosphate buffered saline, demonstrating attenuation of interference from outside the microchannel and tripolar recording of signals from within the microchannel. By using five-lines for 49 active microchannels the device overcomes limitations when connecting many electrodes in a 3-D miniaturized nerve interface.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An ASIC for Recording and Stimulation in Stacked Microchannel Neural Interfaces

Lancashire

Jiang

Demosthenous

et al. 2019

IEEE Trans. Biomed. Circuits Syst.

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“…One in 190 Americans has an amputated limb and over 185,000 new amputations are performed every year [1]. Neuroprosthetic arms available to patients rely on surface electromyographic (EMG) electrodes for motor control [2].…”

mentioning

confidence: 99%

Decellular biological scaffold polymerized with PEDOT for improving peripheral nerve interface charge transfer

Frost

Cederna

Martin

et al. 2014

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Regenerative peripheral nerve interfaces (RPNIs) are for signal transfer between peripheral nerves inside the body to controllers for motorized prosthetics external to the body. Within the residual limb of an amputee, surgical construction of a RPNI connects a remaining peripheral nerve and spare muscle. Nerve signals become concentrated within the RPNI. Currently metal electrodes implanted on the RPNI muscle transfer signals but scarring around metal electrodes progressively diminishes charge transfer. Engineered materials may benefit RPNI signal transfer across the neural interface if they lower the power and charge density of the biologically meaningful signals. Poly3,4-ethylenedioxythiophene (PEDOT) is known to mediate ionic potentials allowing excitation across a critical nerve gap. We hypothesize that the capacity of an interface material to conduct electron mediated current is significantly increased by polymerized coating of PEDOT. SIS was either used plain or after PEDOT coating by electrochemical polymerization. Muscle forces are a direct representation of stimulating current distribution within an RPNI. In situ muscle forces were measured for the same muscle by electrically stimulating: a) the muscle's innervating nerve, b) directly on the muscle, c) on plain SIS laid on the muscle, and d) on SIS polymerized with PEDOT laid on the muscle. Electro-chemically coating PEDOT on SIS resulted in a thin, flexible material. PEDOT coated SIS distributed electrical stimulation more efficiently than SIS alone. Conductive polymer containing biological material allowed ionic signal distribution within the RPNI like muscle at lower charge density.

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