Spiral jet mills: hold up and scale up

Müller, F.; Polke, R.; Schädel, G.

doi:10.1016/b978-0-444-82440-0.50029-8

Cited by 4 publications

(4 citation statements)

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“…Teng et al and Muller et al have been able to illustrate this vortex via simulation and experimentation. 12,13 Particles injected into this gas vortex are accelerated toward the grinding chamber walls by centrifugal force. Particles experience multiple impacts with the wall and other particles.…”

Section: Methodsmentioning

confidence: 99%

Modeling of continuous self‐classifying spiral jet mills part 1: Model structure and validation using mill experiments

et al. 2014

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The objective of this work is to develop a milling model for a continuous self-classifying spiral air jet mill. Its foundation is a population balance model with selection and breakage distribution functions that have been related to a minimal number of mill-dependent and powder-dependent parameters. Initially, experimentation is required to determine the mill-dependent parameters for a specific mill, by milling a "base" powder at multiple operating conditions. Powderdependent parameters can be determined from either mill experiments or from material characterization measurements that require small amounts of powder (presented in Part 2). Ultimately, the milling model presented successfully predicts the product particle size using as inputs the feed particle-size distribution and mill operating conditions. Three crystalline powders, sodium bicarbonate, lactose monohydrate, and sucrose, have been used to test the proposed milling model.

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Section: Methodsmentioning

confidence: 99%

Modeling of continuous self‐classifying spiral jet mills part 1: Model structure and validation using mill experiments

et al. 2014

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“…The main features affecting the efficiency of PS reduction are the GJM design (geometry, number, and angle of nuzzles), operation conditions (feed rate and milling pressure), and material type, specifically the initial PS (Midoux et al., 1999). GJM has the merits of producing microsized particles with a narrow PSD, low product contamination, and low milling temperature that make it appropriate for heat‐sensitive materials (Muller et al., 1996). Moreover, the retention time in the milling process is short as the GJM works in a continuous mode (Palaniandy et al., 2009).…”

Section: Fiber Modification By Dry Mechanical Treatmentsmentioning

confidence: 99%

The applications of conventional and innovative mechanical technologies to tailor structural and functional features of dietary fibers from plant wastes: A review

Fayaz

Soleimanian

Mhamadi

et al. 2022

Comp Rev Food Sci Food Safe

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Plant food wastes generated through the food chain have attracted increasing attention over the last few years not only due to critical environmental and economic issues but also as an available source of valuable components such as dietary fibers. However, the exploitation of plant waste remains limited due to the lack of appropriate processing technologies to recover and tailor fiber functionalities. Among the different technologies developed for waste valorization, mechanical techniques were suggested to be a promising and sustainable strategy to extract fibers with improved functionalities. In this context, the present review describes different mechanical technologies (conventional and innovative) with potential applications to produce micro/nanofibers from various plant residues, highlighting the operating principle as well as the main advantages and pitfalls. The impact on the structural, technological, and functional properties of fibrous materials is comprehensively discussed. The extent of fiber modification not only highly depended on the technology and operation conditions used but also on fiber composition and the application of posttreatments such as dehydration. Other variables, including economic and environmental issues such as equipment cost, energy demand, and eco‐friendly features, are also reviewed. The outputs of this review can be used by both the industrial sector and academia to select a suitable combination of fiber and processing technology for designing novel foods with improved functionalities that fulfill market trends and consumer needs.

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“…Pressurized carrier gas is injected tangentially through the nozzles placed around the chamber generating a high speed fluid vortex in the chamber. This vortex has been visualized with help of computer simulations [1] and also experimentally [2]. The material, introduced into the mill by air pushers exploiting the venturi effect, falls into this fluid vortex and is accelerated to (super)sonic velocities (depending on the type of nozzle used).…”

Section: !'%"('"!mentioning

confidence: 99%

Towards quality by design in pharmaceutical manufacturing: modelling and control of air jet mills

et al. 2017

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&'%' Milling is an important step in pharmaceutical manufacturing as it not only determines the final formulation of the drug product, but also influences the bioavailability and dissolution rate of the active pharmaceutical ingredient (API). In this respect, the air jet mill (AJM) is most commonly used in the pharmaceutical industry as it is a non-contaminating and non-degrading self-classifying process capable of delivering narrow particle size distributions (PSD). Keeping the principles of Quality by Design in mind, the Critical Process Parameters (CPPs) of the AJM have been identified to be the pressures at the grinding nozzles, and the feed rate which affect the PSD, surface charge and the morphology of the product (i.e. the Critical Material Attributes (CMAs)). For the purpose of this research, the PSD is considered to be the only relevant CMA. A population balance based model is proposed to simulate the dynamics milling operation by utilizing the concept of breakage functions. This model agrees qualitatively with experimental observations of the air jet mill unit present at Janssen Pharmaceutica but further steps for model validation need to be carried out.

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Spiral jet mills: hold up and scale up

Cited by 4 publications

References 0 publications

Modeling of continuous self‐classifying spiral jet mills part 1: Model structure and validation using mill experiments

Modeling of continuous self‐classifying spiral jet mills part 1: Model structure and validation using mill experiments

The applications of conventional and innovative mechanical technologies to tailor structural and functional features of dietary fibers from plant wastes: A review

Towards quality by design in pharmaceutical manufacturing: modelling and control of air jet mills

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