Spiraeoside protects human cardiomyocytes against high glucose‐induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway

Li, Hongyang; Zhang, Zhiyong; Zhang, Lei; Yao, Xinliang; Zhang, Xiaoming; Cheng, Guanchang; Wang, Lefeng; Wan, Qilin

doi:10.1002/jbt.22548

Cited by 15 publications

(6 citation statements)

References 34 publications

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“…Quercetin also improve the tricarboxylic acid cycle and respiratory chain-related enzyme activity in rats with myocardial infarction, as well as decrease the expression of biomarkers of myocardial induced oxidative stress in rats with myocardial infarction (140). In addition, quercetin protects AC16 cells from HG-induced oxidative stress by elevating p-SIRT1, endothelial NOS, and decreasing iNOS (141) through the PI3K/Akt/Nrf2 signaling pathway (142).…”

Section: Myocardial Ischemia (M/i) and Reperfusion (Mi/r)mentioning

confidence: 99%

Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

et al. 2022

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Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging-related diseases. Sirtuin 1 (SIRT1), a member of NAD+-dependent deacetylase enzyme family, is extensively explored as a potential therapeutic target for attenuating aging-induced disorders. SIRT1 possess beneficial effects against aging-related diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), Depression, Osteoporosis, Myocardial ischemia (M/I) and reperfusion (MI/R), Atherosclerosis (AS), and Diabetes. Previous studies have reported that aging increases tissue susceptibility, whereas, SIRT1 regulates cellular senescence and multiple aging-related cellular processes, including SIRT1/Keap1/Nrf2/HO-1 and SIRTI/PI3K/Akt/GSK-3β mediated oxidative stress, SIRT1/NF-κB and SIRT1/NLRP3 regulated inflammatory response, SIRT1/PGC1α/eIF2α/ATF4/CHOP and SIRT1/PKD1/CREB controlled phosphorylation, SIRT1-PINK1-Parkin mediated mitochondrial damage, SIRT1/FoxO mediated autophagy, and SIRT1/FoxG1/CREB/BDNF/Trkβ-catenin mediated neuroprotective effects. In this review, we summarized the role of SIRT1 in the improvement of the attenuation effect of quercetin on aging-related diseases and the relationship between relevant signaling pathways regulated by SIRT1. Moreover, the functional regulation of quercetin in aging-related markers such as oxidative stress, inflammatory response, mitochondrial function, autophagy and apoptosis through SIRT1 was discussed. Finally, the prospects of an extracellular vesicles (EVs) as quercetin loading and delivery, and SIRT1-mediated EVs as signal carriers for treating aging-related diseases, as well as discussed the ferroptosis alleviation effects of quercetin to protect against aging-related disease via activating SIRT1. Generally, SIRT1 may serve as a promising therapeutic target in the treatment of aging-related diseases via inhibiting oxidative stress, reducing inflammatory responses, and restoring mitochondrial dysfunction.

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Section: Myocardial Ischemia (M/i) and Reperfusion (Mi/r)mentioning

confidence: 99%

Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

et al. 2022

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“…Table 1 (Ref. [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ]) provides the basic information and mechanisms of 36 flavonoids from recent studies on DCM, while Fig. 2 shows the chemical structures of the 36 flavonoids.…”

Section: Flavonoidsmentioning

confidence: 99%

A Review on the Natural Products in Treatment of Diabetic Cardiomyopathy (DCM)

Yao,

Yang,

Qiao

2024

Rev. Cardiovasc. Med.

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Diabetic cardiomyopathy is an insidious and fatal disease, imposing major financial and social burdens on affected individuals. Among the various methods proposed for the treatment of diabetic cardiomyopathy (DCM), treatments with natural products have achieved promising results due to their high efficiency and minimal side-effects. Literature was searched, analyzed, and collected using databases, including PubMed, Web of Science, Excerpt Medica, Science Direct, and Springer. In this study, we reviewed the DCM-related studies on 72 representative natural products. These natural products have been confirmed to be applicable in the therapeutic intervention of DCM, acting through various mechanisms such as the amelioration of metabolic abnormalities, protecting the mitochondrial structure and function, anti-oxidant stress, anti-inflammatory, anti-fibrosis, regulation of homeostasis and regulation of programmed cell death. The nuclear factor kappa B (NF- B), nuclear factor erythroid 2-related factor 2 (Nrf-2), and transforming growth factor- (TGF- ) have been extensively studied as high frequency signaling pathways for natural product intervention in DCM. The effectiveness of natural products in treating DCM has been revealed and studied, which provides a reference for DCM-specific drug discovery.

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“…In diabetic rats, the blocked PI3K/Akt signaling pathway results in the reduction of protein expression of eNOS, which could also regulate the level of apoptosis [ 112 ]. Liu et al showed that spiraeoside in vitro could upregulate Akt, Nrf2, HO-1, Bcl2, SOD, GPX, and CAT and downregulate caspase3, caspase7, and Bax [ 114 ]. Estrogen receptors- α 36-G protein-coupled estrogen receptor signaling complex could rapidly induce the generating of ceramide, which is necessary for signaling of ceramide-protein kinase C ζ -casein kinase 2 (CK2) [ 115 ].…”

Section: Reviewmentioning

confidence: 99%

The Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling

Gao

Liu

et al. 2022

Oxidative Medicine and Cellular Longevity

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Diabetic cardiomyopathy (DCM) is the main factor responsible for poor prognosis and survival in patients with diabetes. The highly complex pathogenesis of DCM involves multiple signaling pathways, including nuclear factor-κB (NF-κB) signaling pathway, adenosine monophosphate-activated protein kinase (AMPK) signaling pathway, phosphatidylinositol 3-kinase-protein kinase B (Akt) signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway, and transforming growth factor-β (TGF-β) signaling pathway. Nuclear factor erythroid-2-related factor 2 (Nrf2) seems essential to the amelioration of the progression of DCM, not only through counterbalancing oxidative stress, but also through interacting with other signaling pathways to combat inflammation, the disorder in energy homeostasis and insulin signaling, and fibrosis. It has been evidenced that Chinese herbal monomers could attenuate DCM through the crosstalk of Nrf2 with other signaling pathways. This article has summarized the pathogenesis of DCM (especially in oxidative stress), the beneficial effects of ameliorating DCM via the Nrf2 signaling pathway and its crosstalk, and examples of Chinese herbal monomers. It will facilitate pharmacological research and development to promote the utilization of traditional Chinese medicine in DCM.

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Spiraeoside protects human cardiomyocytes against high glucose‐induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway

Cited by 15 publications

References 34 publications

Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

A Review on the Natural Products in Treatment of Diabetic Cardiomyopathy (DCM)

The Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling

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