SPIONs Prepared in Air through Improved Synthesis Methodology: The Influence of γ-Fe2O3/Fe3O4 Ratio and Coating Composition on Magnetic Properties

Matos, Joana C.; Gonçalves, M. Clara; Pereira, Laura C. J.; Vieira, Bruno; Waerenborgh, J.C.

doi:10.3390/nano9070943

Cited by 14 publications

(24 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies [ 1 ] have shown that their unique properties such as high surface area to volume ratios and superparamagnetism (exhibited by particles with a diameter below 30 nm) [ 4 , 5 ] make them suitable for various applications. Therefore, due to their capability to be easily magnetized when they are exposed to the action of an external magnetic field, SPION could be used in various biomedical applications such as: drug and gene delivery [ 6 , 7 ] chelation therapy [ 8 ], hyperthermia [ 9 , 10 ], tissue repair [ 11 , 12 ], etc.…”

Section: Introductionmentioning

confidence: 99%

“…In general, to prevent the agglomeration of nanoparticles and to improve their colloidal stability and biological properties, they are incorporated into polymers (chitosan, dextran, poly(vinyl alcohol)—PVA, gelatin, polyvinylpyrrolidone (PVP), etc.) [ 6 , 13 , 14 , 15 , 16 ]. Dextran, (H(C 6 H 10 O 5 )xOH), is one of the most widely used natural polysaccharides used as a coating for SPION [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

et al. 2021

View full text Add to dashboard Cite

In the present study, we report the synthesis of a dextran coated iron oxide nanoparticles (DIO-NPs) thin layer on glass substrate by an adapted method. The surface morphology of the obtained samples was analyzed by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), optical, and metallographic microscopies. In addition, the distribution of the chemical elements into the DIO-NPs thin layer was analyzed by Glow Discharge Optical Emission Spectrometry (GDOES). Furthermore, the chemical bonds formed between the dextran and iron oxide nanoparticles was investigated by Fourier Transform Infrared Spectroscopy (FTIR). Additionally, the HepG2 viability incubated with the DIO-NPs layers was evaluated at different time intervals using MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The goal of this study was to obtain a DIO-NPs thin layer which could be used as a coating for medical devices such as microfluidic channel, microchips, and catheter. The results of the surface morphology investigations conducted on DIO-NPs thin layer suggests the presence of a continuous and homogeneous layer. In addition, the GDOES results indicate the presence of C, H, Fe, and O signal intensities characteristic to the DIO-NPs layers. The presence in the IR spectra of the Fe-CO metal carbonyl vibration bonds prove that the linkage between iron oxide nanoparticles and dextran take place through carbon–oxygen bonds. The cytotoxicity assays highlighted that HepG2 cells morphology did not show any noticeable modifications after being incubated with DIO-NPs layers. In addition, the MTT assay suggested that the DIO-NPs layers did not present any toxic effects towards HEpG2 cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Sp-GAC showed a major IR shift in the lowfrequency region around 510 cm -1 -570 cm -1 . This is the characteristic vibration of Fe-O-Fe from iron oxide nanoparticles [51]. Therefore, this stated the successful impregnation of iron oxide onto Sp-GAC.…”

Section: Characterization Of Spions Impregnated Activated Carbonmentioning

confidence: 77%

Utilization of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Impregnated Activated Carbon for Removal of Hexavalent Chromium

Farhana

Samrot

et al. 2022

Journal of Nanomaterials

View full text Add to dashboard Cite

Chromium (Cr) is a toxic heavy metal present in industrial effluent which could cause degenerative diseases on ingestion. Therefore, elimination of Cr from contaminated water becomes essential to preserve and sustain the quality of life. In this study, superparamagnetic iron oxide nanoparticles (SPIONs) were impregnated on activated carbon and checked for enhanced removal of Cr(VI). Thus, granular activated carbon (N-GAC) of mesh size 8 ∗ 20 was impregnated with SPIONs to produce SPIONs impregnated activated carbon (Sp-GAC) and characterized using UV-VIS spectrophotometer, FT-IR, SEM-EDX, XRD, and VSM. Sp-GAC was found to be possessing superparamagnetic behavior, and it was used in batch adsorption study where the adsorption parameters like pH, concentration of adsorbent, and adsorbent-adsorbate were optimized. It was found that Cr(VI) adsorption was predominant at acidic pH (pH 3) for both cases; moreover, N-GAC showed better adsorption comparatively. Both the N-GAC and Sp-GAC adsorption were found to be obeying to Langmuir.

show abstract

“…The polymeric materials together with their mono- and co-polymeric entities, have been utilized for in vitro cancer cell lines and in vivo cancer sites drug delivery with the aims of providing stability, transport feasibility, efficient drug targeting, drug deloading at the site, and removal/excretion of residual products, metabolites, and byproducts [ 22 ].…”

Section: Dox Delivery: Spions’ Polymeric Monomeric and Miscellaneous ...mentioning

confidence: 99%

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

et al. 2022

View full text Add to dashboard Cite

Considerable efforts have been directed towards development of nano-structured carriers to overcome the limitations of anticancer drug, doxorubicin’s, delivery to various cancer sites. The drug’s severe toxicity to cardio and hepatic systems, low therapeutic outcomes, inappropriate dose–demands, metastatic and general resistance, together with non-selectivity of the drug have led to the development of superparamagnetic iron oxide nanoparticles (SPIONs)-based drug delivery modules. Nano-scale polymeric co-encapsulation of the drug, doxorubicin, with SPIONs, the SPIONs surface end-groups’ cappings with small molecular entities, as well as structural modifications of the SPIONs’ surface-located functional end-groups, to attach the doxorubicin, have been achieved through chemical bonding by conjugation and cross-linking of natural and synthetic polymers, attachments of SPIONs made directly to the non-polymeric entities, and attachments made through mediation of molecular-spacer as well as non-spacer mediated attachments of several types of chemical entities, together with the physico-chemical bondings of the moieties, e.g., peptides, proteins, antibodies, antigens, aptamers, glycoproteins, and enzymes, etc. to the SPIONs which are capable of targeting multiple kinds of cancerous sites, have provided stable and functional SPIONs–based nano-carriers suitable for the systemic, and in vitro deliveries, together with being suitable for other biomedical/biotechnical applications. Together with the SPIONs inherent properties, and ability to respond to magnetic resonance, fluorescence-directed, dual-module, and molecular-level tumor imaging; as well as multi-modular cancer cell targeting; magnetic-field-inducible drug-elution capacity, and the SPIONs’ magnetometry-led feasibility to reach cancer action sites have made sensing, imaging, and drug and other payloads deliveries to cancerous sites for cancer treatment a viable option. Innovations in the preparation of SPIONs-based delivery modules, as biocompatible carriers; development of delivery route modalities; approaches to enhancing their drug delivery-cum-bioavailability have explicitly established the SPIONs’ versatility for oncological theranostics and imaging. The current review outlines the development of various SPIONs-based nano-carriers for targeted doxorubicin delivery to different cancer sites through multiple methods, modalities, and materials, wherein high-potential nano-structured platforms have been conceptualized, developed, and tested for, both, in vivo and in vitro conditions. The current state of the knowledge in this arena have provided definite dose-control, site-specificity, stability, transport feasibility, and effective onsite drug de-loading, however, with certain limitations, and these shortcomings have opened the field for further advancements by identifying the bottlenecks, suggestive and plausible remediation, as well as more clear directions for future development.

show abstract

SPIONs Prepared in Air through Improved Synthesis Methodology: The Influence of γ-Fe2O3/Fe3O4 Ratio and Coating Composition on Magnetic Properties

Cited by 14 publications

References 46 publications

Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

Preparation and Characterization of Dextran Coated Iron Oxide Nanoparticles Thin Layers

Utilization of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Impregnated Activated Carbon for Removal of Hexavalent Chromium

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

Contact Info

Product

Resources

About