SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release for magnetically guided in vivo tumor therapy

Huang, Hsin Yang; Hu, Shang Hsiu; Hung, Shih Ya; Chiang, Chih Sheng; Liu, Hao Li; Chiu, Tsung Lang; Lai, Hsin Yi; Chen, You Yin; Chen, San‐Yuan

doi:10.1016/j.jconrel.2013.07.029

Cited by 87 publications

(57 citation statements)

References 40 publications

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“…For example, high-intensity focused ultrasound (HIFU) is used to stimulate the intratumoral release of drugs from liposomes 17 , or to locally vaporize perfluorocarbons in micro/nano-bubbles to generate high-resolution ultrasound imaging 18 . Inorganic nanoparticles, e.g.…”

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confidence: 99%

Antitumor Efficacy of Irreversible Electroporation and Doxorubicin-Loaded Polymeric Micelles

et al. 2015

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Irreversible electroporation (IRE) is a novel non-thermal ablative treatment for cancer patients with unresectable tumor. IRE kills tumor cells by applying a strong electric field across the cell membrane, thereby creating irreparable pores. Compared to conventional thermal ablation, IRE is effective in perivascular tissues and can preserve the surrounding sensitive structures. However, tumor cells may survive in the regions exposed to insufficient electric field strength, and cause tumor relapse afterwards. We prepared a doxorubicin-loaded polymeric micelles system (M-Dox) using oil-in-water emulsion. The resultant M-Dox was 37.9 ± 3.2 nm in size with a Dox loading of 4.3% by weight. M-Dox is toxic to multiple human cancer cell lines with IC50 values in nanomolar and micromolar range. When combined with IRE in a hepatic carcinoma mouse xenograft model, the tumor treated with the combination therapy (IRE + M-Dox) was the highest in both M-Dox uptake and percentage of necrosis. Immunohistochemical staining also confirmed that the fewest proliferating cells were present after the combination therapy. Our data suggested that M-Dox was an effective adjuvant treatment to enhance the anti-tumor efficacy of IRE.

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confidence: 99%

Antitumor Efficacy of Irreversible Electroporation and Doxorubicin-Loaded Polymeric Micelles

et al. 2015

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“…The highest RV release rate was 89.7 AE 3.1% aer US irradiation for 60 s. These results showed that RILMBs-FA exhibited a suitable US-triggered drug release capability, likely due to the destruction of microbubbles leading to drug release. [34][35][36][37] 3.2 In vitro cellular uptake and biocompatibility Fig. 4a shows that intense ICG red uorescence could be observed in the perinuclear region in RILMBs-FA treated cells compared to that of free ICG and RILMBs treated cells.…”

Section: Preparation and Characterization Of Rilmbs-famentioning

confidence: 99%

Indocyanine green conjugated lipid microbubbles as an ultrasound-responsive drug delivery system for dual-imaging guided tumor-targeted therapy

Huang

et al. 2018

RSC Adv.

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“…Generally, anti‐cancer drug therapy has low therapeutic efficiency because of its low tumor‐targeting efficiency and adverse effects on normal cells. For the improvement of cancer treatment, various types of drug delivery microrobot has been studied; microrobot has high targeting and efficiency as anti‐cancer drug (Danhier et al, ; Edwards et al, ; Grüll et al, ; Huang et al, ; Kim et al, ; Liu et al, ; Mathieu and Martel, ; Park et al, ; Pouponneau et al, 2009, 2011; Veiseh et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

A hybrid actuated microrobot using an electromagnetic field and flagellated bacteria for tumor‐targeting therapy

Choi

Cho

et al. 2015

Biotech & Bioengineering

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In this paper, we propose a new concept for a hybrid actuated microrobot for tumor-targeting therapy. For drug delivery in tumor therapy, various electromagnetic actuated microrobot systems have been studied. In addition, bacteria-based microrobot (so-called bacteriobot), which use tumor targeting and the therapeutic function of the bacteria, has also been proposed for solid tumor therapy. Compared with bacteriobot, electromagnetic actuated microrobot has larger driving force and locomotive controllability due to their position recognition and magnetic field control. However, because electromagnetic actuated microrobot does not have self-tumor targeting, they need to be controlled by an external magnetic field. In contrast, the bacteriobot uses tumor targeting and the bacteria's own motility, and can exhibit self-targeting performance at solid tumors. However, because the propulsion forces of the bacteria are too small, it is very difficult for bacteriobot to track a tumor in a vessel with a large bloodstream. Therefore, we propose a hybrid actuated microrobot combined with electromagnetic actuation in large blood vessels with a macro range and bacterial actuation in small vessels with a micro range. In addition, the proposed microrobot consists of biodegradable and biocompatible microbeads in which the drugs and magnetic particles can be encapsulated; the bacteria can be attached to the surface of the microbeads and propel the microrobot. We carried out macro-manipulation of the hybrid actuated microrobot along a desired path through electromagnetic field control and the micro-manipulation of the hybrid actuated microrobot toward a chemical attractant through the chemotaxis of the bacteria. For the validation of the hybrid actuation of the microrobot, we fabricated a hydrogel microfluidic channel that can generate a chemical gradient. Finally, we evaluated the motility performance of the hybrid actuated microrobot in the hydrogel microfluidic channel. We expect that the hybrid actuated microrobot will be utilized for tumor targeting and therapy in future.

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SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release for magnetically guided in vivo tumor therapy

Cited by 87 publications

References 40 publications

Antitumor Efficacy of Irreversible Electroporation and Doxorubicin-Loaded Polymeric Micelles

Antitumor Efficacy of Irreversible Electroporation and Doxorubicin-Loaded Polymeric Micelles

Indocyanine green conjugated lipid microbubbles as an ultrasound-responsive drug delivery system for dual-imaging guided tumor-targeted therapy

A hybrid actuated microrobot using an electromagnetic field and flagellated bacteria for tumor‐targeting therapy

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