“…Yet, infantile and childhood onset has been described in many spinocerebellar ataxias, including SCA2, SCA7, SCA10, SCA13, SCA14, SCA21, SCA25, SCA28, SCA29, SCA42, SCA44, and dentatorubral-pallidoluysian atrophy. 68,69 Some cases can be explained by the phenomenon of anticipation, with earlier onset and more severe presentation in subsequent generations that is typical of expansion-repeat disorders. 68 In the uncommon situation of autosomal dominant ataxia presenting in childhood, the phenotype tends to be more severe and complex than pure ataxia.…”