Abstract:The balance between serine proteases, kallikreins (KLKs), and their inhibitor, Kazal type‐5 (SPINK5), is important to maintain steady desquamation. To explore regulation of SPINK5 expression in skin, its promoters (nucleotide ‐676/‐532 and ‐318/‐146 from the major transcription start site) were subjected to luciferase assay because these two sides displayed high luciferase intensity in NHEK human keratinocyte. Electrophoretic mobility shift assay (EMSA) appeared specific nuclear protein binding to these two si… Show more
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