Spinel ferrite nanoparticles and nanocomposites for biomedical applications and their toxicity

Kefeni, Kebede K.; Msagati, Titus A.M.; Nkambule, Thabo T.I.; Mamba, Bhekie B.

doi:10.1016/j.msec.2019.110314

Cited by 190 publications

(108 citation statements)

References 301 publications

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“…Among different MNPs, iron oxide-based NPs, especially spinel ferrites, have recently emerged as popular candidates for emerging biomedical applications due to their chemical stability, biocompatibility, the reasonable cost compared to the other MNPs such as silver NPs (i.e., gold standard anti-bacterial NPs), and their unique ferromagnetic properties [ 22 , 23 ]. Spinel ferrites are homogenous materials consisting primarily of iron and have a general chemical formula of MFe 2 O 4 , in which M 2+ and Fe 3+ respectively reside in tetrahedral and octahedral metallic cation spots of the lattice [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

et al. 2021

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Background Increasing antibiotic resistance continues to focus on research into the discovery of novel antimicrobial agents. Due to its antimicrobial and wound healing-promoting activity, metal nanoparticles have attracted attention for dermatological applications. This study is designed to investigate the scope and bactericidal potential of zinc ferrite nanoparticles (ZnFe2O4 NPs), and the mechanism of anti-bacterial action along with cytocompatibility, hemocompatibility, and wound healing properties. Results ZnFe2O4 NPs were synthesized via a modified co-precipitation method. Structure, size, morphology, and elemental compositions of ZnFe2O4 NPs were analyzed using X-ray diffraction pattern, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy. In PrestoBlue and live/dead assays, ZnFe2O4 NPs exhibited dose-dependent cytotoxic effects on human dermal fibroblasts. In addition, the hemocompatibility assay revealed that the NPs do not significantly rupture red blood cells up to a dose of 1000 µg/mL. Bacterial live/dead imaging and zone of inhibition analysis demonstrated that ZnFe2O4 NPs showed dose-dependent bactericidal activities in various strains of Gram-negative and Gram-positive bacteria. Interestingly, NPs showed antimicrobial activity through multiple mechanisms, such as cell membrane damage, protein leakage, and reactive oxygen species generation, and were more effective against gram-positive bacteria. Furthermore, in vitro scratch assay revealed that ZnFe2O4 NPs improved cell migration and proliferation of cells, with noticeable shrinkage of the artificial wound model. Conclusions This study indicated that ZnFe2O4 NPs have the potential to be used as a future antimicrobial and wound healing drug.

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Section: Introductionmentioning

confidence: 99%

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

et al. 2021

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“…In recent years, developments of magnetic nanoparticles have been receiving significant attention due to a wide range of potential applications and high absorption in the superparamagnetic characteristics, high surface-to-volume ratio, etc [1] . Spinel ferrites are the most attractive ferrite because of the presence of magnetic and electrical properties such as high saturation magnetization (Ms) as well as high dielectric properties and initial permeability, low eddy current loss [2] , [3] , [4] . they are used in broad applications such as biomedical imaging as MRI contrast agents [2] , [5] , drug delivery [2] , [5] , [6] , diagnostic of COVID-19 [7] , wastewater treatment [8] , nanofluids [9] , visible light–enabled active photodegradation [10] , gas sensing [5] , Energy storage [5] , high-frequency antennas [5] , electromagnetic interference (EMI) shielding [5] , multilayer chip inductors (MLCIs) [4] , etc.…”

Section: Introductionmentioning

confidence: 99%

Effect of reaction condition on microstructure and properties of (NiCuZn)Fe2O4 nanoparticles synthesized via co-precipitation with ultrasonic irradiation

Peng

Xia

Cui

et al. 2021

Ultrasonics Sonochemistry

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Highlights Crystallites sizes of nanoparticles synthesized via ultrasound irradiation were less than 40nm. Ms and Hc of nanoparticles obtained at 25℃ were higher than at 50℃ under the same power. The samples exhibited the highest Ms at 25℃ and the lowest Hc at 50℃ both for 60W. The ultrasonic irradiation had a positive effect on improving the ferrite magnetic properties.

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“…The large O 2− ions produce a face-centered cubic lattice. The cubic cell has two types of interstitial sites: (1) tetrahedral sites enclosed via 4 oxygen anions (A-site), (2) octahedral sites enclosed by 6 oxygen anions (B-site) (Shah et al 2018;Yadav et al 2018;Kefeni et al 2020). Figure 1 shows the tetrahedral and octahedral positions in the FCC lattice (Cullity and Graham 2011;AJMAL 2009;Vijayanand 2010;Bhame 2007;Sachdev 2006).…”

Section: Supercapacitor-based On Spinel Ferritesmentioning

confidence: 99%

Advanced materials and technologies for supercapacitors used in energy conversion and storage: a review

et al. 2020

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Supercapacitors are increasingly used for energy conversion and storage systems in sustainable nanotechnologies. Graphite is a conventional electrode utilized in Li-ion-based batteries, yet its specific capacitance of 372 mA h g −1 is not adequate for supercapacitor applications. Interest in supercapacitors is due to their high-energy capacity, storage for a shorter period and longer lifetime. This review compares the following materials used to fabricate supercapacitors: spinel ferrites, e.g., MFe 2 O 4 , MMoO 4 and MCo 2 O 4 where M denotes a transition metal ion; perovskite oxides; transition metals sulfides; carbon materials; and conducting polymers. The application window of perovskite can be controlled by cations in sublattice sites. Cations increase the specific capacitance because cations possess large orbital valence electrons which grow the oxygen vacancies. Electrodes made of transition metal sulfides, e.g., ZnCo 2 S 4 , display a high specific capacitance of 1269 F g −1 , which is four times higher than those of transition metals oxides, e.g., Zn-Co ferrite, of 296 F g −1. This is explained by the low charge-transfer resistance and the high ion diffusion rate of transition metals sulfides. Composites made of magnetic oxides or transition metal sulfides with conducting polymers or carbon materials have the highest capacitance activity and cyclic stability. This is attributed to oxygen and sulfur active sites which foster electrolyte penetration during cycling, and, in turn, create new active sites.

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Spinel ferrite nanoparticles and nanocomposites for biomedical applications and their toxicity

Cited by 190 publications

References 301 publications

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

Anti‐bacterial and wound healing‐promoting effects of zinc ferrite nanoparticles

Effect of reaction condition on microstructure and properties of (NiCuZn)Fe2O4 nanoparticles synthesized via co-precipitation with ultrasonic irradiation

Advanced materials and technologies for supercapacitors used in energy conversion and storage: a review

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