Spine metastases: Current treatments and future directions

Harel, Ran; Angelov, Lilyana

doi:10.1016/j.ejca.2010.04.025

Cited by 171 publications

(182 citation statements)

References 125 publications

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“…10,17 Early detection and proper intervention are critical to minimizing the sequelae from spine metastases, reestablishing function, and maximizing the quality of life. 18 There was almost perfect inter-and intraobserver reliability in the total SINS scores for the three clinically relevant evaluations of tumor-related instability, which can be described as stable (score from 0 to 6), indeterminate (imminent from 7 to 12), and unstable (13 to 18). 8,17,19 We observed that all the examiners rated it as important in daily practice and capable of changing their conduct in relation to a case.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Scores in Decision Making in Metastases of the Spine

et al. 2015

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Objective: The aim of this study is to assess the intra-and interobserver concordance of SINS, Harrington, Tokuhashi and Tomita scores among general orthopedic surgeons and spine surgeons with experience above 5 and 10 years in the evaluation of patients with spinal metastasis. Methods: Twenty cases of patients with metastatic lesion of the spine were presented to 10 examiners and the scores aforementioned have been applied. After six weeks, the cases were reintroduced in a different order and data were analyzed. Results: The intraobserver reliability showed better agreement in SINS score among examiners with less experience and Harrington and Tomita scores among those who had more than 10-year experience. The interobserver reliability of the examiners of the group with over 10-year experience showed higher precision when using these scores, especially Harrington and Tomita. The SINS score was the choice for daily practice and was able to modify the management more often. Conclusions: This study demonstrated that the use of predictive scores of instability, Harrington, and prognosis, Tomita, had a higher intra-and interobserver reliability particularly among spine surgeons with experience above 10 years.Keywords: Prognosis; Neoplasm metastasis; Spinal neoplasms; Life expectancy. RESUMO Objetivo: O objetivo deste estudo é avaliar a concordância intra e interobservador dos escores SINS, Harrington

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Section: Discussionmentioning

confidence: 99%

Assessment of Scores in Decision Making in Metastases of the Spine

et al. 2015

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“…The spine is the most common site for skeletal metastases, and the incidence of spinal metastasis tends to increase due to the increase in older populations and improvements in medical treatment, such as chemotherapy and radiotherapy (1,2). However, previous reports have focused on tumor detection and the differential diagnosis with other diseases and it was insufficient to provide physicians with practical information for the treatment of spinal metastasis.…”

Section: Introductionmentioning

confidence: 99%

“…Patients may present with radicular abnormalities, myelopathic abnormalities or a combination of both (3,6,10). As much as 10% of cancer patients can show symptomatic spinal metastasis at their initial presentation, and pain is the most common symptom of spinal metastasis (2). Pain is classified as three, classic pain syndromes, i.e.…”

Section: Neural Compressionmentioning

confidence: 99%

Interpretation of MR Imaging of Spinal Metastasis: Focus on the Understanding of Its Pathophysiology and the Next Step toward a Further Clinical Approach Using MRI Findings

Lee

2016

Investig Magn Reson Imaging

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The spine is the most common location for skeletal metastases, and the incidence of spinal metastasis shows an increasing tendency. Because metastatic spinal tumors progress from an anterior element to a posterior element resulting in continuing destruction of the pedicles, epidural extension and involvement of neural structures of the metastatic tumor are eventually visible. Therefore, it is clinically significant for radiologists to understand the pathophysiology of spinal metastasis and to assess the involvement of neural structures and the disintegration of spinal instability related to the pathophysiology. As MRI is also the best imaging modality for diagnosing spinal metastasis, radiologists should accurately assess spinal metastasis and provide practical information to physicians. Therefore, we will describe some analysis points focusing on the understanding of pathophysiology of spinal metastasis and the next step toward a more extensive clinical approach using MR imaging.

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“…(<5%) (HAREL & ANGELOV, 2010). It is believed that bone involvement can be explained based on the bone features that render the bone fertile for tumor growth, predisposing it to spinal metastases.…”

Section: Microscopicamente Ambos Os Neoplasmas Primários Eram Caractmentioning

confidence: 99%